1-cycloheksylcarbonylaminomethylperhydroisoquinoline

Base Information

• Chemical Name: 1-cycloheksylcarbonylaminomethylperhydroisoquinoline
• CAS No.: 120340-96-7
• Molecular Formula: C₁₇H₃₀N₂O
• Molecular Weight: 278.438
• Mol file: 120340-96-7.mol

Synonyms:1-cycloheksylcarbonylaminomethylperhydroisoquinoline

Chemical Property of 1-cycloheksylcarbonylaminomethylperhydroisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-cycloheksylcarbonylaminomethylperhydroisoquinoline

There total 3 articles about 1-cycloheksylcarbonylaminomethylperhydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.4%

1-Aminomethylperhydroisoquinoline Dihydrochloride (120367-94-4) + cyclohexanylcarbonyl chloride (2719-27-9) → 1-cycloheksylcarbonylaminomethylperhydroisoquinoline (120340-96-7)

Guidance literature:

With pyridine; sodium hydroxide; In acetonitrile; at 20 ℃; for 3h;

DOI:10.1007/BF00479350

Reference yield:

1-Phthalimidomethyl-3,4,5,6,7,8-hexahydroisoquinoline hydrochloride → 1-cycloheksylcarbonylaminomethylperhydroisoquinoline (120340-96-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 68 percent / H₂ / platinum oxide / H₂O; acetic acid / 3 h / Ambient temperature

2: 54 percent / 18percent aq. HCl / 10 h / Heating

3: 82.4 percent / 2N NaOH, pyridine / acetonitrile / 3 h / 20 °C

With pyridine; hydrogenchloride; sodium hydroxide; hydrogen; platinum(IV) oxide; In water; acetic acid; acetonitrile;

DOI:10.1007/BF00479350

Reference yield:

1-Phthalimidomethylperhydroisoquinoline Hydrochloride → 1-cycloheksylcarbonylaminomethylperhydroisoquinoline (120340-96-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 54 percent / 18percent aq. HCl / 10 h / Heating

2: 82.4 percent / 2N NaOH, pyridine / acetonitrile / 3 h / 20 °C

With pyridine; hydrogenchloride; sodium hydroxide; In acetonitrile;

DOI:10.1007/BF00479350

upstream raw materials:

1-Aminomethylperhydroisoquinoline Dihydrochloride

cyclohexanylcarbonyl chloride

Downstream raw materials:

2-Cyclohexylcarbonyl-4-oxoperhydropyrazino<2,1-a>isoquinoline

Refernces