Technology Process of 2-bromo-7-nitro-5H-pyrrolo[2,3-b]pyrazine
There total 1 articles about 2-bromo-7-nitro-5H-pyrrolo[2,3-b]pyrazine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sulfuric acid; nitric acid;
at 10 - 20 ℃;
for 1.5h;
- Guidance literature:
-
2-bromo-7-nitro-5H-pyrrolo[2,3-b]pyrazine;
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
for 0.5h;
Inert atmosphere;
Cooling with ice;
trityl chloride;
In
N,N-dimethyl-formamide; mineral oil;
at 20 ℃;
With
water;
In
N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Inert atmosphere; Cooling with ice
1.2: 20 °C
2.1: hydrogenchloride; indium / water; tetrahydrofuran / 0.08 h
3.1: sodium carbonate / bis(tri-t-butylphosphine)palladium(0) / 1,4-dioxane / 1 h / 65 °C / Inert atmosphere; Microwave irradiation
4.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 3 h / 20 °C
5.1: trifluoroacetic acid; triethylsilane / dichloromethane / 20 °C
With
hydrogenchloride; triethylsilane; indium; sodium hydride; sodium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; trifluoroacetic acid;
bis(tri-t-butylphosphine)palladium(0);
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
