(1S)-1,2,3,4-tetrahydro-6-hydroxy-7-methoxy-1-methoxycarbonyl-1-methyl-2-<<(R)-1-phenylethyl>carbamoyl>isoquinoline

Base Information

Chemical Name:(1S)-1,2,3,4-tetrahydro-6-hydroxy-7-methoxy-1-methoxycarbonyl-1-methyl-2-<<(R)-1-phenylethyl>carbamoyl>isoquinoline
CAS No.:110691-60-6
Molecular Formula:C₂₂H₂₆N₂O₅
Molecular Weight:398.459
Hs Code.:

Synonyms:(1S)-1,2,3,4-tetrahydro-6-hydroxy-7-methoxy-1-methoxycarbonyl-1-methyl-2-<<(R)-1-phenylethyl>carbamoyl>isoquinoline

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Chemical Property of (1S)-1,2,3,4-tetrahydro-6-hydroxy-7-methoxy-1-methoxycarbonyl-1-methyl-2-<<(R)-1-phenylethyl>carbamoyl>isoquinoline

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Technology Process of (1S)-1,2,3,4-tetrahydro-6-hydroxy-7-methoxy-1-methoxycarbonyl-1-methyl-2-<<(R)-1-phenylethyl>carbamoyl>isoquinoline

There total 3 articles about (1S)-1,2,3,4-tetrahydro-6-hydroxy-7-methoxy-1-methoxycarbonyl-1-methyl-2-<<(R)-1-phenylethyl>carbamoyl>isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 33375-06-3
(1R)-1-phenylethyl isocyanate

: 110691-59-3
Methyl(+/-)-Salsoline-1-methylcarboxylate

: 110691-61-7
(1R)-1,2,3,4-tetrahydro-6-hydroxy-7-methoxy-1-methoxycarbonyl-1-methyl-2-<<(R)-1-phenylethyl>carbamoyl>isoquinoline

: 110691-60-6
(1S)-1,2,3,4-tetrahydro-6-hydroxy-7-methoxy-1-methoxycarbonyl-1-methyl-2-<<(R)-1-phenylethyl>carbamoyl>isoquinoline

Guidance literature:: In chloroform; 1.) 0 deg C, 2h, 2.) to r.t.;

Reference yield:

: 88598-26-9,31758-50-6
salsoline-1-carboxylic acid

: 110691-60-6
(1S)-1,2,3,4-tetrahydro-6-hydroxy-7-methoxy-1-methoxycarbonyl-1-methyl-2-<<(R)-1-phenylethyl>carbamoyl>isoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / SOCl₂ / 0 deg C, then 5 h, reflux

2: 21 percent / CHCl₃ / 2 h / 0 °C

With thionyl chloride; In chloroform;
DOI:10.1002/hlca.19860690620

Reference yield:

: 645-33-0
3-hydroxy-4-methoxy-β-phenethylamine hydrochloride

: 110691-60-6
(1S)-1,2,3,4-tetrahydro-6-hydroxy-7-methoxy-1-methoxycarbonyl-1-methyl-2-<<(R)-1-phenylethyl>carbamoyl>isoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / aq. ammonia / 18 h / 32 °C / pH = 7 (adjusted with HCl)

2: 55 percent / SOCl₂ / 1.) reflux, 5 h, 2.) 20 deg C, overnight, 3.) reflux, 1.5 h

3: 41 percent / CHCl₃ / 1.) 0 deg C, 2h, 2.) to r.t.

With ammonium hydroxide; thionyl chloride; In chloroform;