{[3,5-Bis-(benzyloxycarbonylmethyl-carbamoyl)-1,3,5-trimethyl-cyclohexanecarbonyl]-amino}-acetic acid benzyl ester

Base Information

• Chemical Name: {[3,5-Bis-(benzyloxycarbonylmethyl-carbamoyl)-1,3,5-trimethyl-cyclohexanecarbonyl]-amino}-acetic acid benzyl ester
• CAS No.: 183888-50-8
• Molecular Formula: C₃₉H₄₅N₃O₉
• Molecular Weight: 699.801
• Mol file: 183888-50-8.mol

Synonyms:{[3,5-Bis-(benzyloxycarbonylmethyl-carbamoyl)-1,3,5-trimethyl-cyclohexanecarbonyl]-amino}-acetic acid benzyl ester

Chemical Property of {[3,5-Bis-(benzyloxycarbonylmethyl-carbamoyl)-1,3,5-trimethyl-cyclohexanecarbonyl]-amino}-acetic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {[3,5-Bis-(benzyloxycarbonylmethyl-carbamoyl)-1,3,5-trimethyl-cyclohexanecarbonyl]-amino}-acetic acid benzyl ester

There total 1 articles about {[3,5-Bis-(benzyloxycarbonylmethyl-carbamoyl)-1,3,5-trimethyl-cyclohexanecarbonyl]-amino}-acetic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Kemp's triacid (79410-20-1) + glycine benzyl ester p-toluenesulfonic acid salt (1738-76-7) → {[3,5-Bis-(benzyloxycarbonylmethyl-carbamoyl)-1,3,5-trimethyl-cyclohexanecarbonyl]-amino}-acetic acid benzyl ester (183888-50-8)

Guidance literature:

With TEA; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; Yield given. Multistep reaction; 1.) DMF, 0 deg C, 5 min, 2.) DMF, RT, 4 h;

DOI:10.1021/ja961260c

Reference yield: 97.0%

{[3,5-Bis-(benzyloxycarbonylmethyl-carbamoyl)-1,3,5-trimethyl-cyclohexanecarbonyl]-amino}-acetic acid benzyl ester (183888-50-8) → {[3,5-Bis-(carboxymethyl-carbamoyl)-1,3,5-trimethyl-cyclohexanecarbonyl]-amino}-acetic acid (183888-51-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1021/ja961260c

Reference yield:

{[3,5-Bis-(benzyloxycarbonylmethyl-carbamoyl)-1,3,5-trimethyl-cyclohexanecarbonyl]-amino}-acetic acid benzyl ester (183888-50-8) → 1,3,5-Trimethyl-cyclohexane-1,3,5-tricarboxylic acid tris-[({2-[(S)-2-((2S,4R)-2-carbamoyl-4-hydroxy-pyrrolidine-1-carbonyl)-pyrrolidin-1-yl]-2-oxo-ethylcarbamoyl}-methyl)-amide]

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / H₂ / 10percent Pd/C / methanol

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1021/ja961260c

upstream raw materials:

Kemp's triacid

glycine benzyl ester p-toluenesulfonic acid salt

Downstream raw materials:

{[3,5-Bis-(carboxymethyl-carbamoyl)-1,3,5-trimethyl-cyclohexanecarbonyl]-amino}-acetic acid