N-[(benzyloxy)methyl]-N-(2-bromo-5-chlorophenyl)-3-(3-chlorophenyl)-2-(3-methoxyphenyl)propanamide

Base Information

Chemical Name:N-[(benzyloxy)methyl]-N-(2-bromo-5-chlorophenyl)-3-(3-chlorophenyl)-2-(3-methoxyphenyl)propanamide
CAS No.:1416038-35-1
Molecular Formula:C₃₀H₂₆BrCl₂NO₃
Molecular Weight:599.351
Hs Code.:

Synonyms:N-[(benzyloxy)methyl]-N-(2-bromo-5-chlorophenyl)-3-(3-chlorophenyl)-2-(3-methoxyphenyl)propanamide

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Chemical Property of N-[(benzyloxy)methyl]-N-(2-bromo-5-chlorophenyl)-3-(3-chlorophenyl)-2-(3-methoxyphenyl)propanamide

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Technology Process of N-[(benzyloxy)methyl]-N-(2-bromo-5-chlorophenyl)-3-(3-chlorophenyl)-2-(3-methoxyphenyl)propanamide

There total 3 articles about N-[(benzyloxy)methyl]-N-(2-bromo-5-chlorophenyl)-3-(3-chlorophenyl)-2-(3-methoxyphenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 3587-60-8
Benzyloxymethyl chloride

: 1416038-34-0
N-(2-bromo-5-chlorophenyl)-3-(3-chlorophenyl)-2-(3-methoxyphenyl)propanamide

: 1416038-35-1
N-[(benzyloxy)methyl]-N-(2-bromo-5-chlorophenyl)-3-(3-chlorophenyl)-2-(3-methoxyphenyl)propanamide

Guidance literature:: N-(2-bromo-5-chlorophenyl)-3-(3-chlorophenyl)-2-(3-methoxyphenyl)propanamide; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

Benzyloxymethyl chloride; In tetrahydrofuran; at 0 - 20 ℃; for 20h;
DOI:10.1002/hlca.201200477

Reference yield:

: 1798-09-0
m-methoxyphenylacetic acid

: 1416038-35-1
N-[(benzyloxy)methyl]-N-(2-bromo-5-chlorophenyl)-3-(3-chlorophenyl)-2-(3-methoxyphenyl)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / 16 h / -78 - 20 °C

2.1: thionyl chloride / 8 h / Reflux

3.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C

4.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 20 °C

4.2: 20 h / 0 - 20 °C

With thionyl chloride; sodium hydride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1002/hlca.201200477

Reference yield:

: 766-80-3
1-bromomethyl-3-chlorobenzene

: 1416038-35-1
N-[(benzyloxy)methyl]-N-(2-bromo-5-chlorophenyl)-3-(3-chlorophenyl)-2-(3-methoxyphenyl)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / 16 h / -78 - 20 °C

2.1: thionyl chloride / 8 h / Reflux

3.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C

4.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 20 °C

4.2: 20 h / 0 - 20 °C

With thionyl chloride; sodium hydride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1002/hlca.201200477