1-[2-(tert-butyldimethylsiloxy)phenyl]-5-[1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-pent-3-yn-1-one

Base Information

Chemical Name:1-[2-(tert-butyldimethylsiloxy)phenyl]-5-[1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-pent-3-yn-1-one
CAS No.:827575-42-8
Molecular Formula:C₂₉H₃₇NO₄SSi
Molecular Weight:523.769
Hs Code.:

Synonyms:1-[2-(tert-butyldimethylsiloxy)phenyl]-5-[1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-pent-3-yn-1-one

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Chemical Property of 1-[2-(tert-butyldimethylsiloxy)phenyl]-5-[1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-pent-3-yn-1-one

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Technology Process of 1-[2-(tert-butyldimethylsiloxy)phenyl]-5-[1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-pent-3-yn-1-one

There total 5 articles about 1-[2-(tert-butyldimethylsiloxy)phenyl]-5-[1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-pent-3-yn-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 827575-29-1
4-but-3-ynyl-1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydropyridine

: 827575-54-2
2-(tert-butyldimethylsilanyloxy)-benzoyl chloride

: 827575-42-8
1-[2-(tert-butyldimethylsiloxy)phenyl]-5-[1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-pent-3-yn-1-one

Guidance literature:: With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; for 24h;
DOI:10.1021/ol047696b

Reference yield:

: 827575-53-1
6-methoxy-1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydropyridine

: 827575-42-8
1-[2-(tert-butyldimethylsiloxy)phenyl]-5-[1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-pent-3-yn-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: Mg / tetrahydrofuran / 1.17 h

1.2: 83 percent / CuBr*DMS / tetrahydrofuran / 22 h / -15 - 20 °C

2.1: 96 percent / K₂CO₃ / methanol / 15 h / 20 °C

3.1: 72 percent / CuI; Et₃N / (PPh₃)2PdCl₂ / CH₂Cl₂ / 24 h

With copper(l) iodide; potassium carbonate; magnesium; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ol047696b

Reference yield:

: 827575-52-0
3-bromo-2-methoxy-1-(toluene-4-sulfonyl)piperidine

: 827575-42-8
1-[2-(tert-butyldimethylsiloxy)phenyl]-5-[1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-pent-3-yn-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 83 percent / DBU / dimethylformamide / 20 h / 90 °C

2.1: Mg / tetrahydrofuran / 1.17 h

2.2: 83 percent / CuBr*DMS / tetrahydrofuran / 22 h / -15 - 20 °C

3.1: 96 percent / K₂CO₃ / methanol / 15 h / 20 °C

4.1: 72 percent / CuI; Et₃N / (PPh₃)2PdCl₂ / CH₂Cl₂ / 24 h

With copper(l) iodide; potassium carbonate; magnesium; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol047696b