4-(4-iodo-2,6-dimethyl-phenyl)-3,5-dimethyl-pyridine

Base Information

• Chemical Name: 4-(4-iodo-2,6-dimethyl-phenyl)-3,5-dimethyl-pyridine
• CAS No.: 865087-56-5
• Molecular Formula: C₁₅H₁₆IN
• Molecular Weight: 337.203
• Mol file: 865087-56-5.mol

Synonyms:4-(4-iodo-2,6-dimethyl-phenyl)-3,5-dimethyl-pyridine

Chemical Property of 4-(4-iodo-2,6-dimethyl-phenyl)-3,5-dimethyl-pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-iodo-2,6-dimethyl-phenyl)-3,5-dimethyl-pyridine

There total 10 articles about 4-(4-iodo-2,6-dimethyl-phenyl)-3,5-dimethyl-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

4-(3,5-dimethylpyridin-4-yl)-3,5-dimethyl-phenylamine (865087-49-6) → 4-(4-iodo-2,6-dimethyl-phenyl)-3,5-dimethyl-pyridine (865087-56-5)

Guidance literature:

4-(3,5-dimethylpyridin-4-yl)-3,5-dimethyl-phenylamine; With nitrosonium tetrafluoroborate; In acetonitrile; at -30 ℃; for 1h;

With sodium iodide; In acetonitrile; at -30 - 20 ℃;

DOI:10.1021/ol051365x

Reference yield:

4-(3,5-dimethylpyridin-4-yl)-3,5-dimethyl-phenol (865087-46-3) → 4-(4-iodo-2,6-dimethyl-phenyl)-3,5-dimethyl-pyridine (865087-56-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 92.8 percent / pyridine / 6 h / 20 °C

2.1: 97.7 percent / Cs₂CO₃; BINAP / Pd(OAc)2 / tetrahydrofuran / 15 h / 65 °C

3.1: 99 percent / NaOAc; NH₂OH*HCl / methanol / 1.5 h / 20 °C

4.1: nitrosonium tetrafluoroborate / acetonitrile / 1 h / -30 °C

4.2: 72 percent / NaI / acetonitrile / -30 - 20 °C

With pyridine; hydroxylamine hydrochloride; sodium acetate; caesium carbonate; nitrosonium tetrafluoroborate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; In tetrahydrofuran; methanol; acetonitrile;

DOI:10.1021/ja0674690

Reference yield:

4-(4-methoxy-2,6-dimethylphenyl)-3,5-dimethyl-pyridine (865087-45-2) → 4-(4-iodo-2,6-dimethyl-phenyl)-3,5-dimethyl-pyridine (865087-56-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 91.6 percent / pyridine*HCl / 3 h / 210 °C

2.1: 92.8 percent / pyridine / 6 h / 20 °C

3.1: 97.7 percent / Cs₂CO₃; BINAP / Pd(OAc)2 / tetrahydrofuran / 15 h / 65 °C

4.1: 99 percent / NaOAc; NH₂OH*HCl / methanol / 1.5 h / 20 °C

5.1: nitrosonium tetrafluoroborate / acetonitrile / 1 h / -30 °C

5.2: 72 percent / NaI / acetonitrile / -30 - 20 °C

With pyridine; hydroxylamine hydrochloride; sodium acetate; pyridine hydrochloride; caesium carbonate; nitrosonium tetrafluoroborate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; In tetrahydrofuran; methanol; acetonitrile;

DOI:10.1021/ja0674690

upstream raw materials:

4-(3,5-dimethylpyridin-4-yl)-3,5-dimethyl-phenylamine

4-(4-methoxy-2,6-dimethylphenyl)-3,5-dimethyl-pyridine

4-(3,5-dimethylpyridin-4-yl)-3,5-dimethyl-phenol

4-(4-methoxy-2,6-dimethylphenyl)-3,5-dimethyl-pyridin-1-ol

Downstream raw materials:

2-[4-(3,5-dimethyl-pyridin-4-yl)-3,5-dimethyl-phenyl]-malononitrile

2,6-di-tert-butyl-4-{2-[4-(3,5-dimethyl-pyridin-4-yl)-3,5-dimethyl-phenyl]-vinyl}phenol