2'-O-(tert-butyldimethylsilyl)-2-debenzoyl-4-deacetyl-1,2-carbonato-4-(O-benzylglutaryl)-6,7-dehydropaclitaxel

Base Information

Chemical Name:2'-O-(tert-butyldimethylsilyl)-2-debenzoyl-4-deacetyl-1,2-carbonato-4-(O-benzylglutaryl)-6,7-dehydropaclitaxel
CAS No.:248272-50-6
Molecular Formula:C₅₇H₆₇NO₁₅Si
Molecular Weight:1034.24
Hs Code.:

Synonyms:2'-O-(tert-butyldimethylsilyl)-2-debenzoyl-4-deacetyl-1,2-carbonato-4-(O-benzylglutaryl)-6,7-dehydropaclitaxel

Suppliers and Price of 2'-O-(tert-butyldimethylsilyl)-2-debenzoyl-4-deacetyl-1,2-carbonato-4-(O-benzylglutaryl)-6,7-dehydropaclitaxel

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2'-O-(tert-butyldimethylsilyl)-2-debenzoyl-4-deacetyl-1,2-carbonato-4-(O-benzylglutaryl)-6,7-dehydropaclitaxel

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2'-O-(tert-butyldimethylsilyl)-2-debenzoyl-4-deacetyl-1,2-carbonato-4-(O-benzylglutaryl)-6,7-dehydropaclitaxel

There total 1 articles about 2'-O-(tert-butyldimethylsilyl)-2-debenzoyl-4-deacetyl-1,2-carbonato-4-(O-benzylglutaryl)-6,7-dehydropaclitaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 54322-10-0
glutaric acid monobenzyl ester

: 248272-48-2
2'-O-(tert-butyldimethylsilyl)-2-debenzoyl-4-deacetyl-1,2-carbonato-6,7-dehydropaclitaxel

: 248272-50-6
2'-O-(tert-butyldimethylsilyl)-2-debenzoyl-4-deacetyl-1,2-carbonato-4-(O-benzylglutaryl)-6,7-dehydropaclitaxel

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In toluene; for 96h; Ambient temperature;
DOI:10.1016/S0040-4020(99)00552-9

Reference yield: 81.0%

: 248272-50-6
2'-O-(tert-butyldimethylsilyl)-2-debenzoyl-4-deacetyl-1,2-carbonato-4-(O-benzylglutaryl)-6,7-dehydropaclitaxel

: 248272-51-7
2'-O-(tert-butyldimethylsilyl)-2-debenzoyl-4-deacetyl-1,2-carbonato-4-(O-benzylglutaryl)-6α-hydroxy-7-epipaclitaxel

Guidance literature:: With osmium(VIII) oxide; 4-methylmorpholine N-oxide; In water; acetone; for 40h; Ambient temperature;
DOI:10.1016/S0040-4020(99)00552-9

Reference yield:

: 248272-50-6
2'-O-(tert-butyldimethylsilyl)-2-debenzoyl-4-deacetyl-1,2-carbonato-4-(O-benzylglutaryl)-6,7-dehydropaclitaxel

: 248272-53-9
2'-O-(tert-butyldimethylsilyl)-4-deacetyl-4-glutaryl-6α-hydroxy-7-epipaclitaxel

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / OsO₄, N-methylmorpholine-N-oxide / H₂O; acetone / 40 h / Ambient temperature

2: 87 percent / H₂ / Pd/C / ethyl acetate / 2 h

3: 78 percent / tetrahydrofuran; hexane / 0.33 h / -78 °C

With osmium(VIII) oxide; hydrogen; 4-methylmorpholine N-oxide; palladium on activated charcoal; In tetrahydrofuran; hexane; water; ethyl acetate; acetone;
DOI:10.1016/S0040-4020(99)00552-9