4-(2-{3,3-dimethyl-5-[4-(trifluoromethyl)phenyl]-2,3-dihydro-1H-indol-1-yl}-2-oxoethyl)-2-methoxyphenol

Base Information

Chemical Name:4-(2-{3,3-dimethyl-5-[4-(trifluoromethyl)phenyl]-2,3-dihydro-1H-indol-1-yl}-2-oxoethyl)-2-methoxyphenol
CAS No.:847064-35-1
Molecular Formula:C₂₆H₂₄F₃NO₃
Molecular Weight:455.477
Hs Code.:

Synonyms:4-(2-{3,3-dimethyl-5-[4-(trifluoromethyl)phenyl]-2,3-dihydro-1H-indol-1-yl}-2-oxoethyl)-2-methoxyphenol

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Chemical Property of 4-(2-{3,3-dimethyl-5-[4-(trifluoromethyl)phenyl]-2,3-dihydro-1H-indol-1-yl}-2-oxoethyl)-2-methoxyphenol

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Technology Process of 4-(2-{3,3-dimethyl-5-[4-(trifluoromethyl)phenyl]-2,3-dihydro-1H-indol-1-yl}-2-oxoethyl)-2-methoxyphenol

There total 1 articles about 4-(2-{3,3-dimethyl-5-[4-(trifluoromethyl)phenyl]-2,3-dihydro-1H-indol-1-yl}-2-oxoethyl)-2-methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 844901-56-0
3,3-dimethyl-5-[4-(trifluoromethyl)phenyl]-2,3-dihydro-1H-indole

: 306-08-1
Homovanillic acid

: 847064-35-1
4-(2-{3,3-dimethyl-5-[4-(trifluoromethyl)phenyl]-2,3-dihydro-1H-indol-1-yl}-2-oxoethyl)-2-methoxyphenol

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,2-dichloro-ethane; at 0 - 20 ℃;

Reference yield: 88.0%

: 847064-35-1
4-(2-{3,3-dimethyl-5-[4-(trifluoromethyl)phenyl]-2,3-dihydro-1H-indol-1-yl}-2-oxoethyl)-2-methoxyphenol

: 5292-43-3
bromoacetic acid tert-butyl ester

: tert-butyl[4-(2-{3,3-dimethyl-5-[4-(trifluoromethyl)phenyl]-2,3-dihydro-1H-indol-1-yl}-2-oxoethyl)-2-methoxyphenoxy] acetate

Guidance literature:: 4-(2-{3,3-dimethyl-5-[4-(trifluoromethyl)phenyl]-2,3-dihydro-1H-indol-1-yl}-2-oxoethyl)-2-methoxyphenol; With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 1h;

bromoacetic acid tert-butyl ester; In DMF (N,N-dimethyl-formamide); at 20 - 50 ℃;