cyclo--5-methylheptanoyl>oxy-3-oxo-2,5-dimethylhexanoyl>-L-leucyl>-L-prolyl-N-methyl-L-phenylalanyl>-L-threonyl>

Base Information

Chemical Name:cyclo--5-methylheptanoyl>oxy-3-oxo-2,5-dimethylhexanoyl>-L-leucyl>-L-prolyl-N-methyl-L-phenylalanyl>-L-threonyl>
CAS No.:220657-30-7
Molecular Formula:C₅₅H₉₁N₅O₁₂Si
Molecular Weight:1042.44
Hs Code.:

cyclo-<N-(tert-butyloxycarbonyl)-O-<<N-<(2S,4S)-4-<(3S,4R,5S)-4-amino-3-<(triisopropylsilyl)oxy>-5-methylheptanoyl>oxy-3-oxo-2,5-dimethylhexanoyl>-L-leucyl>-L-prolyl-N-methyl-L-phenylalanyl>-L-threonyl>

Synonyms:cyclo--5-methylheptanoyl>oxy-3-oxo-2,5-dimethylhexanoyl>-L-leucyl>-L-prolyl-N-methyl-L-phenylalanyl>-L-threonyl>

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Chemical Property of cyclo--5-methylheptanoyl>oxy-3-oxo-2,5-dimethylhexanoyl>-L-leucyl>-L-prolyl-N-methyl-L-phenylalanyl>-L-threonyl>

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Technology Process of cyclo--5-methylheptanoyl>oxy-3-oxo-2,5-dimethylhexanoyl>-L-leucyl>-L-prolyl-N-methyl-L-phenylalanyl>-L-threonyl>

There total 2 articles about cyclo--5-methylheptanoyl>oxy-3-oxo-2,5-dimethylhexanoyl>-L-leucyl>-L-prolyl-N-methyl-L-phenylalanyl>-L-threonyl> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 220657-28-3
cyclo--5-methylheptanoyl>oxy-3-hydroxy-2,5-dimethylhexanoyl>-L-leucyl>-L-prolyl-N-methyl-L-phenylalanyl>-L-threonyl>

: 220657-30-7
cyclo--5-methylheptanoyl>oxy-3-oxo-2,5-dimethylhexanoyl>-L-leucyl>-L-prolyl-N-methyl-L-phenylalanyl>-L-threonyl>

Guidance literature:: With Dess-Martin periodane; In dichloromethane; for 2h;
DOI:10.1016/S0040-4020(98)01042-4

Reference yield:

: 220657-26-1
cyclo--5-methylheptanoyl>oxy-3-(methoxymethoxy)-2,5-dimethylhexanoyl>-L-leucyl>-L-prolyl-N-methyl-L-phenylalanyl>-L-threonyl>

: 220657-30-7
cyclo--5-methylheptanoyl>oxy-3-oxo-2,5-dimethylhexanoyl>-L-leucyl>-L-prolyl-N-methyl-L-phenylalanyl>-L-threonyl>

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / Me₂BBr / CH₂Cl₂ / 1.5 h / -78 °C

2: 73 percent / Dess Martin periodinane / CH₂Cl₂ / 2 h

With dimethylboron bromide; Dess-Martin periodane; In dichloromethane;
DOI:10.1016/S0040-4020(98)01042-4

Reference yield:

: 220657-30-7
cyclo--5-methylheptanoyl>oxy-3-oxo-2,5-dimethylhexanoyl>-L-leucyl>-L-prolyl-N-methyl-L-phenylalanyl>-L-threonyl>

: cyclo-N-L-lactyl-L-prolyl-N-methyl-D-leucine-oxy-3-oxo-2,5-dimethylhexanoyl>-L-leucyl>-L-prolyl-N-methyl-L-phenylalanyl>-L-threonyl>

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) HCl / 1.) EtOAc, -20 deg C to -10 deg C, 30 min, 2.) -20 deg C to -10 deg C, 2 h; 0 deg C, 4 h

2: 92 percent / BOP, NMM / CH₂Cl₂ / 1.) 0 deg C, 30 min, 2.) room temperature, 3 h

With 4-methyl-morpholine; hydrogenchloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In dichloromethane;
DOI:10.1016/S0040-4020(98)01042-4