3,5-bis<2-<<1,1-dimethylethyl)dimethylsilyl>oxy>-6-hydroxyphenyl>-1,6-dihydropyridazine

Base Information

• Chemical Name: 3,5-bis<2-<<1,1-dimethylethyl)dimethylsilyl>oxy>-6-hydroxyphenyl>-1,6-dihydropyridazine
• CAS No.: 122763-59-1
• Molecular Formula: C₂₈H₄₂N₂O₄Si₂
• Molecular Weight: 526.823
• Mol file: 122763-59-1.mol

Synonyms:3,5-bis<2-<<1,1-dimethylethyl)dimethylsilyl>oxy>-6-hydroxyphenyl>-1,6-dihydropyridazine

Chemical Property of 3,5-bis<2-<<1,1-dimethylethyl)dimethylsilyl>oxy>-6-hydroxyphenyl>-1,6-dihydropyridazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-bis<2-<<1,1-dimethylethyl)dimethylsilyl>oxy>-6-hydroxyphenyl>-1,6-dihydropyridazine

There total 1 articles about 3,5-bis<2-<<1,1-dimethylethyl)dimethylsilyl>oxy>-6-hydroxyphenyl>-1,6-dihydropyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

3-methyl-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-1,2-benzisoxazole (122763-52-4) → 3,5-bis<2-<<1,1-dimethylethyl)dimethylsilyl>oxy>-6-hydroxyphenyl>-1,6-dihydropyridazine (122763-59-1)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -75 ℃; for 0.166667h;

DOI:10.1021/jo00281a050

Reference yield: 74.0%

3,5-bis<2-<<1,1-dimethylethyl)dimethylsilyl>oxy>-6-hydroxyphenyl>-1,6-dihydropyridazine (122763-59-1) → 3,5-bis<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-6-hydroxyphenyl>pyridazine (122763-60-4)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; for 1h; Ambient temperature;

DOI:10.1021/jo00281a050

Reference yield:

3,5-bis<2-<<1,1-dimethylethyl)dimethylsilyl>oxy>-6-hydroxyphenyl>-1,6-dihydropyridazine (122763-59-1) → 3,5-bis(2,6-dihydroxyphenyl)pyridazine (122763-64-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / MnO₂ / CH₂Cl₂ / 1 h / Ambient temperature

2: Bu₄NF / tetrahydrofuran

With manganese(IV) oxide; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo00281a050

upstream raw materials:

3-methyl-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-1,2-benzisoxazole

Downstream raw materials:

3,5-bis<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-6-hydroxyphenyl>pyridazine

3,5-bis(2,6-dihydroxyphenyl)pyridazine

tetrakis(tert-butyldimethylsilyl) ether