(2S,3S)-1-(bis(4-methoxy-3,5-dimethylphenyl)methyl)-2-phenyl-3-((S)-tetrahydrofuran-2-yl)aziridine

Base Information

Chemical Name:(2S,3S)-1-(bis(4-methoxy-3,5-dimethylphenyl)methyl)-2-phenyl-3-((S)-tetrahydrofuran-2-yl)aziridine
CAS No.:1253176-67-8
Molecular Formula:C₃₁H₃₇NO₃
Molecular Weight:471.64
Hs Code.:

Synonyms:(2S,3S)-1-(bis(4-methoxy-3,5-dimethylphenyl)methyl)-2-phenyl-3-((S)-tetrahydrofuran-2-yl)aziridine

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Chemical Property of (2S,3S)-1-(bis(4-methoxy-3,5-dimethylphenyl)methyl)-2-phenyl-3-((S)-tetrahydrofuran-2-yl)aziridine

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Technology Process of (2S,3S)-1-(bis(4-methoxy-3,5-dimethylphenyl)methyl)-2-phenyl-3-((S)-tetrahydrofuran-2-yl)aziridine

There total 2 articles about (2S,3S)-1-(bis(4-methoxy-3,5-dimethylphenyl)methyl)-2-phenyl-3-((S)-tetrahydrofuran-2-yl)aziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1253176-43-0
1-((2S,3S)-1-(bis(4-methoxy-3,5-dimethyl-phenyl)methyl)-3-phenylaziridin-2-yl)-4-bromobutan-1-one

: 1253176-67-8
(2S,3S)-1-(bis(4-methoxy-3,5-dimethylphenyl)methyl)-2-phenyl-3-((S)-tetrahydrofuran-2-yl)aziridine

: 1253176-68-9
(2S,3S)-1-(bis(4-methoxy-3,5-dimethylphenyl)methyl)-2-phenyl-3-((R)-tetrahydrofuran-2-yl)aziridine

Guidance literature:: With L-Selectride; In tetrahydrofuran; at 25 ℃; for 24h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ol102064b

Reference yield:

: 146580-95-2
5-Bromo-1-diazopentan-2-one

: 1253176-67-8
(2S,3S)-1-(bis(4-methoxy-3,5-dimethylphenyl)methyl)-2-phenyl-3-((S)-tetrahydrofuran-2-yl)aziridine

: 1253176-68-9
(2S,3S)-1-(bis(4-methoxy-3,5-dimethylphenyl)methyl)-2-phenyl-3-((R)-tetrahydrofuran-2-yl)aziridine

Guidance literature:: Multi-step reaction with 2 steps

1: C₄₄H₃₀B₃O₇^(1-)*H⁽¹⁺⁾ / toluene / 24 h / 25 °C / Inert atmosphere

2: L-Selectride / tetrahydrofuran / 24 h / 25 °C / Inert atmosphere

With C₄₄H₃₀B₃O₇^(1-)*H⁽¹⁺⁾; L-Selectride; In tetrahydrofuran; toluene;
DOI:10.1021/ol102064b