4'-(2''-deoxy-5''-O-dimethoxytrityl-β-D-ribofuranosyl)-2,3,4,5,6-pentafluorobiphenyl

Base Information

Chemical Name:4'-(2''-deoxy-5''-O-dimethoxytrityl-β-D-ribofuranosyl)-2,3,4,5,6-pentafluorobiphenyl
CAS No.:852378-32-6
Molecular Formula:C₃₈H₃₁F₅O₅
Molecular Weight:662.653
Hs Code.:

Synonyms:4'-(2''-deoxy-5''-O-dimethoxytrityl-β-D-ribofuranosyl)-2,3,4,5,6-pentafluorobiphenyl

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Chemical Property of 4'-(2''-deoxy-5''-O-dimethoxytrityl-β-D-ribofuranosyl)-2,3,4,5,6-pentafluorobiphenyl

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Technology Process of 4'-(2''-deoxy-5''-O-dimethoxytrityl-β-D-ribofuranosyl)-2,3,4,5,6-pentafluorobiphenyl

There total 10 articles about 4'-(2''-deoxy-5''-O-dimethoxytrityl-β-D-ribofuranosyl)-2,3,4,5,6-pentafluorobiphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 852378-31-5
1,2-dideoxy-1β-[4-(2,3,4,5,6-pentafluorophenyl)phenyl]-D-ribofuranose

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 852378-32-6
4'-(2''-deoxy-5''-O-dimethoxytrityl-β-D-ribofuranosyl)-2,3,4,5,6-pentafluorobiphenyl

Guidance literature:: With pyridine; at 20 ℃; for 2h;
DOI:10.1002/chem.200401128

Reference yield:

: 852378-27-9
4'-(β-D-ribofuranosyl)-2,3,4,5,6-pentafluorobiphenyl

: 852378-32-6
4'-(2''-deoxy-5''-O-dimethoxytrityl-β-D-ribofuranosyl)-2,3,4,5,6-pentafluorobiphenyl

Guidance literature:: Multi-step reaction with 5 steps

1: 78 percent / pyridine / 16 h / 20 °C

2: 90 percent / acetonitrile / 32 h / 20 °C

3: 88 percent / AIBN; tris(trimethylsilyl)silane / toluene / 0.5 h / 85 °C

4: 82 percent / (HF)3*NEt₃ / tetrahydrofuran / 16 h / 20 °C

5: 87 percent / pyridine / 2 h / 20 °C

With pyridine; 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane; triethylamine tris(hydrogen fluoride); In tetrahydrofuran; toluene; acetonitrile;
DOI:10.1002/chem.200401128

Reference yield:

: 852378-30-4
4'-(3'',5''-O-(1,1,3,3-tetraisopropyl)disiloxanediyl-2''-deoxy-β-D-ribofuranosyl)-2,3,4,5,6-pentafluorobiphenyl

: 852378-32-6
4'-(2''-deoxy-5''-O-dimethoxytrityl-β-D-ribofuranosyl)-2,3,4,5,6-pentafluorobiphenyl

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / (HF)3*NEt₃ / tetrahydrofuran / 16 h / 20 °C

2: 87 percent / pyridine / 2 h / 20 °C

With pyridine; triethylamine tris(hydrogen fluoride); In tetrahydrofuran;
DOI:10.1002/chem.200401128