1-[[2-(3-chlorophenyl)-5-cyclopropyl-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(2-methylsulfonylethyl)phenyl]urea

Base Information

Chemical Name:1-[[2-(3-chlorophenyl)-5-cyclopropyl-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(2-methylsulfonylethyl)phenyl]urea
CAS No.:1402582-00-6
Molecular Formula:C₂₃H₂₄ClFN₄O₃S
Molecular Weight:490.986
Hs Code.:

Synonyms:1-[[2-(3-chlorophenyl)-5-cyclopropyl-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(2-methylsulfonylethyl)phenyl]urea

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Chemical Property of 1-[[2-(3-chlorophenyl)-5-cyclopropyl-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(2-methylsulfonylethyl)phenyl]urea

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Technology Process of 1-[[2-(3-chlorophenyl)-5-cyclopropyl-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(2-methylsulfonylethyl)phenyl]urea

There total 6 articles about 1-[[2-(3-chlorophenyl)-5-cyclopropyl-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(2-methylsulfonylethyl)phenyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1254716-76-1
(1-(3-chlorophenyl)-3-cyclopropyl-1H-pyrazol-5-yl)methanamine

: 1402586-47-3
phenyl 3-fluoro-4-(2-(methylsulfonyl)ethyl)phenylcarbamate

: 1402582-00-6
1-[[2-(3-chlorophenyl)-5-cyclopropyl-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(2-methylsulfonylethyl)phenyl]urea

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 150 ℃; for 1h; under 5250.53 Torr; Microwave irradiation;

Reference yield:

: 1221119-68-1
2-(2-fluoro-4-nitrophenyl)ethan-1-ol

: 1402582-00-6
1-[[2-(3-chlorophenyl)-5-cyclopropyl-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(2-methylsulfonylethyl)phenyl]urea

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid; hydrogen bromide / water / 3 h / 100 °C / Cooling

2: isopropyl alcohol / 10 h / 23 - 70 °C

3: palladium 10% on activated carbon; hydrogen / ethyl acetate / 2 h / Inert atmosphere

4: pyridine / N,N-dimethyl-formamide; acetone / 1 h / 0 - 20 °C

5: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 150 °C / 5250.53 Torr / Microwave irradiation

With pyridine; sulfuric acid; palladium 10% on activated carbon; hydrogen bromide; hydrogen; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; acetone;

Reference yield:

: 1402586-44-0
1-(2-bromoethyl)-2-fluoro-4-nitrobenzene

: 1402582-00-6
1-[[2-(3-chlorophenyl)-5-cyclopropyl-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(2-methylsulfonylethyl)phenyl]urea

Guidance literature:: Multi-step reaction with 4 steps

1: isopropyl alcohol / 10 h / 23 - 70 °C

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 2 h / Inert atmosphere

3: pyridine / N,N-dimethyl-formamide; acetone / 1 h / 0 - 20 °C

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 150 °C / 5250.53 Torr / Microwave irradiation

With pyridine; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; acetone;