tert-butyl 3-methyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}butanoate

Base Information

Chemical Name:tert-butyl 3-methyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}butanoate
CAS No.:1191412-72-2
Molecular Formula:C₂₅H₃₀N₂O₄
Molecular Weight:422.524
Hs Code.:

Synonyms:tert-butyl 3-methyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}butanoate

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Chemical Property of tert-butyl 3-methyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}butanoate

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Technology Process of tert-butyl 3-methyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}butanoate

There total 4 articles about tert-butyl 3-methyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 28669-17-2
2-phenyl-4H-1,3,4-oxadiazin-5(6H)-one

: 197659-58-8
tert-butyl 2-[4-(bromomethyl)phenyl]-3-methylbutanoate

: 1191412-72-2
tert-butyl 3-methyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}butanoate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1021/acs.jmedchem.0c02154

Reference yield:

: 197659-39-5
tert-butyl 3-methyl-2-(4-methylphenyl)butanoate

: 1191412-72-2
tert-butyl 3-methyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}butanoate

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / dichloromethane / 2 h / Reflux

2: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); caesium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.0c02154

Reference yield:

: 33155-60-1
t-butyl p-tolylacetate

: 1191412-72-2
tert-butyl 3-methyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}butanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

1.2: 4 h / 0 °C / Inert atmosphere

2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / dichloromethane / 2 h / Reflux

3.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium tert-butylate; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.0c02154