Ethyl 5-(3-chloro-4-fluorophenyl)-4-(3-cyano-5-fluorophenyl)furan-2-carboxylate

Base Information

Chemical Name:Ethyl 5-(3-chloro-4-fluorophenyl)-4-(3-cyano-5-fluorophenyl)furan-2-carboxylate
CAS No.:1231209-02-1
Molecular Formula:C₂₀H₁₂ClF₂NO₃
Molecular Weight:387.77
Hs Code.:

Synonyms:Ethyl 5-(3-chloro-4-fluorophenyl)-4-(3-cyano-5-fluorophenyl)furan-2-carboxylate

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Chemical Property of Ethyl 5-(3-chloro-4-fluorophenyl)-4-(3-cyano-5-fluorophenyl)furan-2-carboxylate

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Technology Process of Ethyl 5-(3-chloro-4-fluorophenyl)-4-(3-cyano-5-fluorophenyl)furan-2-carboxylate

There total 2 articles about Ethyl 5-(3-chloro-4-fluorophenyl)-4-(3-cyano-5-fluorophenyl)furan-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 935685-88-4
3-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenecarbonitrile

: 1231208-93-7
Ethyl 4-bromo-5-(3-chloro-4-fluorophenyl)furan-2-carboxylate

: 1231209-02-1
Ethyl 5-(3-chloro-4-fluorophenyl)-4-(3-cyano-5-fluorophenyl)furan-2-carboxylate

Guidance literature:: With caesium carbonate; XPhos; palladium diacetate; In 1,2-dimethoxyethane; at 50 ℃; for 48h; Inert atmosphere;

Reference yield:

: 179898-34-1
3-bromo-5-fluorobenzonitrile

: 1231209-02-1
Ethyl 5-(3-chloro-4-fluorophenyl)-4-(3-cyano-5-fluorophenyl)furan-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; dimethyl sulfoxide / 90 °C / Inert atmosphere

2: caesium carbonate; XPhos / palladium diacetate / 1,2-dimethoxyethane / 48 h / 50 °C / Inert atmosphere

With potassium acetate; caesium carbonate; XPhos; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; In 1,4-dioxane; 1,2-dimethoxyethane; dimethyl sulfoxide; 1: Suzuki Coupling;

Reference yield:

: 1231209-02-1
Ethyl 5-(3-chloro-4-fluorophenyl)-4-(3-cyano-5-fluorophenyl)furan-2-carboxylate

: 1231209-20-3
C₁₈H₈ClF₂NO₃

Guidance literature:: Ethyl 5-(3-chloro-4-fluorophenyl)-4-(3-cyano-5-fluorophenyl)furan-2-carboxylate; With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃;

With hydrogenchloride; In tetrahydrofuran; water;