4-[2-(2-AMino-4,5,6,7-tetrahydro-4,6-dioxo-3H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoic Acid Methyl Ester

Base Information

Chemical Name:4-[2-(2-AMino-4,5,6,7-tetrahydro-4,6-dioxo-3H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoic Acid Methyl Ester
CAS No.:1320346-43-7
Molecular Formula:C₁₆H₁₆N₄O₄
Molecular Weight:328.327
Hs Code.:
Mol file:1320346-43-7.mol

Synonyms:methyl 4-[2-(2-amino-4,6-dioxo-4,5,6,7-tetrahydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoate

Suppliers and Price of 4-[2-(2-AMino-4,5,6,7-tetrahydro-4,6-dioxo-3H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoic Acid Methyl Ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-[2-(2-Amino-4,5,6,7-tetrahydro-4,6-dioxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoicAcidMethylEster
25mg
$ 150.00

Medical Isotopes, Inc.
4-[2-(2-Amino-4,5,6,7-tetrahydro-4,6-dioxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoicAcidMethylEster
250 mg
$ 2200.00

Medical Isotopes, Inc.
4-[2-(2-Amino-4,5,6,7-tetrahydro-4,6-dioxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoicAcidMethylEster
25 mg
$ 650.00

Total 3 raw suppliers

Chemical Property of 4-[2-(2-AMino-4,5,6,7-tetrahydro-4,6-dioxo-3H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoic Acid Methyl Ester

Chemical Property:

Melting Point:>267°C (dec.)
Storage Temp.:Refrigerator
Solubility.:DMSO, Methanol

Purity/Quality:

≥95% ^*data from raw suppliers

4-[2-(2-Amino-4,5,6,7-tetrahydro-4,6-dioxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoicAcidMethylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Used in the preparation of a Pemetrexed (P219500) metabolite.

Technology Process of 4-[2-(2-AMino-4,5,6,7-tetrahydro-4,6-dioxo-3H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoic Acid Methyl Ester

There total 3 articles about 4-[2-(2-AMino-4,5,6,7-tetrahydro-4,6-dioxo-3H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoic Acid Methyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1320346-37-9
C₁₂H₁₂Br₂O₃

: 56-06-4
2,6-diaminopyrimidin-4-ol

: 1320346-43-7
methyl 4-[2-(2-amino-4,6-dioxo-4,5,6,7-tetrahydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoate

Guidance literature:: C₁₂H₁₂Br₂O₃; 2,6-diaminopyrimidin-4-ol; In water; acetonitrile; for 0.0833333h;

With sodium acetate; In water; acetonitrile; Reflux;
DOI:10.1016/j.tetlet.2011.05.141

Reference yield:

: 619-42-1
4-methoxycarbonylphenyl bromide

: 1320346-43-7
methyl 4-[2-(2-amino-4,6-dioxo-4,5,6,7-tetrahydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(l) iodide; diethylamine; triphenylphosphine; palladium dichloride / 4 h / 50 °C

1.2: 3.5 h / 2585.81 Torr

1.3: 1 h / -10 - 0 °C

2.1: hydrogen bromide; bromine; acetic acid / dichloromethane / Reflux

3.1: water; acetonitrile / 0.08 h

3.2: Reflux

With copper(l) iodide; hydrogen bromide; bromine; acetic acid; diethylamine; triphenylphosphine; palladium dichloride; In dichloromethane; water; acetonitrile;
DOI:10.1016/j.tetlet.2011.05.141

Reference yield:

: 106200-41-3
4-(4-carbomethoxyphenyl)butanal

: 1320346-43-7
methyl 4-[2-(2-amino-4,6-dioxo-4,5,6,7-tetrahydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen bromide; bromine; acetic acid / dichloromethane / Reflux

2.1: water; acetonitrile / 0.08 h

2.2: Reflux

With hydrogen bromide; bromine; acetic acid; In dichloromethane; water; acetonitrile;
DOI:10.1016/j.tetlet.2011.05.141