N-(4-amino-5-chloro-2-methoxyphenyl)-4-(4-fluorobenzyl)-2-morpholineacetamide

Base Information

Chemical Name:N-(4-amino-5-chloro-2-methoxyphenyl)-4-(4-fluorobenzyl)-2-morpholineacetamide
CAS No.:1026881-25-3
Molecular Formula:C₂₀H₂₃ClFN₃O₃
Molecular Weight:407.872
Hs Code.:

Synonyms:N-(4-amino-5-chloro-2-methoxyphenyl)-4-(4-fluorobenzyl)-2-morpholineacetamide

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Chemical Property of N-(4-amino-5-chloro-2-methoxyphenyl)-4-(4-fluorobenzyl)-2-morpholineacetamide

Chemical Property:

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Technology Process of N-(4-amino-5-chloro-2-methoxyphenyl)-4-(4-fluorobenzyl)-2-morpholineacetamide

There total 4 articles about N-(4-amino-5-chloro-2-methoxyphenyl)-4-(4-fluorobenzyl)-2-morpholineacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 170804-85-0
N-(5-chloro-2-methoxy-4-nitrophenyl)-4-(4-fluorobenzyl)-2-morpholineacetamide

: 1026881-25-3
N-(4-amino-5-chloro-2-methoxyphenyl)-4-(4-fluorobenzyl)-2-morpholineacetamide

Guidance literature:: With hydrogenchloride; tin(ll) chloride; In acetic acid; for 15h; Ambient temperature;
DOI:10.1016/0223-5234(96)88276-6

Reference yield:

: [4-(4-Fluoro-benzyl)-morpholin-2-yl]-acetic acid ethyl ester

: 1026881-25-3
N-(4-amino-5-chloro-2-methoxyphenyl)-4-(4-fluorobenzyl)-2-morpholineacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / 20percent aq. HCl / 6 h / Heating

2: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH₂Cl₂ / 6 h / Ambient temperature

3: conc. H₂SO₄, HNO₃ / acetic acid / 3 h / Ambient temperature

4: 72 percent / SnCl₂, conc. HCl / acetic acid / 15 h / Ambient temperature

With hydrogenchloride; sulfuric acid; nitric acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tin(ll) chloride; In dichloromethane; acetic acid;
DOI:10.1016/0223-5234(96)88276-6

Reference yield:

: 170804-81-6
N-(5-chloro-2-methoxyphenyl)-4-(4-fluorobenzyl)-2-morpholineacetamide

: 1026881-25-3
N-(4-amino-5-chloro-2-methoxyphenyl)-4-(4-fluorobenzyl)-2-morpholineacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: conc. H₂SO₄, HNO₃ / acetic acid / 3 h / Ambient temperature

2: 72 percent / SnCl₂, conc. HCl / acetic acid / 15 h / Ambient temperature

With hydrogenchloride; sulfuric acid; nitric acid; tin(ll) chloride; In acetic acid;
DOI:10.1016/0223-5234(96)88276-6