[(R)-Cyclohexyl-(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-phosphonic acid (R)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl ester 4-nitro-benzyl ester

Base Information

• Chemical Name: [(R)-Cyclohexyl-(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-phosphonic acid (R)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl ester 4-nitro-benzyl ester
• CAS No.: 169436-71-9
• Molecular Formula: C₄₀H₄₁N₄O₈P
• Molecular Weight: 736.761

Synonyms:[(R)-Cyclohexyl-(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-phosphonic acid (R)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl ester 4-nitro-benzyl ester

Chemical Property of [(R)-Cyclohexyl-(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-phosphonic acid (R)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl ester 4-nitro-benzyl ester

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Technology Process of [(R)-Cyclohexyl-(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-phosphonic acid (R)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl ester 4-nitro-benzyl ester

There total 5 articles about [(R)-Cyclohexyl-(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-phosphonic acid (R)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl ester 4-nitro-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

β-indolyllactamide (159830-26-9) + C29H30ClN2O6P (159830-25-8) → [(R)-Cyclohexyl-(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-phosphonic acid (R)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl ester 4-nitro-benzyl ester (169436-71-9)

Guidance literature:

With silver cyanide; 4 A molecular sieve; In benzene; for 5h; Yield given; Heating;

DOI:10.1016/0040-4039(94)85022-4

Reference yield:

[(R)-Cyclohexyl-(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-phosphonic acid mono-(4-nitro-benzyl) ester (159830-24-7) → [(R)-Cyclohexyl-(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-phosphonic acid (R)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl ester 4-nitro-benzyl ester (169436-71-9)

Guidance literature:

Multi-step reaction with 2 steps

1: (COCl)2, DMF / CH₂Cl₂ / 0.5 h / 0 °C

2: AgCN, Et₃N / benzene / 2 h / Heating

With silver cyanide; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane; benzene;

DOI:10.1021/ja962465o

Reference yield:

C29H30ClN2O6P (159830-25-8) → [(R)-Cyclohexyl-(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-phosphonic acid (R)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl ester 4-nitro-benzyl ester (169436-71-9)

Guidance literature:

Multi-step reaction with 2 steps

2: AgCN

With silver cyanide;

DOI:10.1021/ja962465o

upstream raw materials:

β-indolyllactamide

C₂₉H₃₀ClN₂O₆P

[(R)-Cyclohexyl-(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-phosphonic acid mono-(4-nitro-benzyl) ester

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