{4-[(di-tert-butoxyphosphoryl)(difluoro)methyl]benzyl}malonic acid, benzyl methyl ester

Base Information

• Chemical Name: {4-[(di-tert-butoxyphosphoryl)(difluoro)methyl]benzyl}malonic acid, benzyl methyl ester
• CAS No.: 345953-51-7
• Molecular Formula: C₂₇H₃₅F₂O₇P
• Molecular Weight: 540.541

Synonyms:{4-[(di-tert-butoxyphosphoryl)(difluoro)methyl]benzyl}malonic acid, benzyl methyl ester

Chemical Property of {4-[(di-tert-butoxyphosphoryl)(difluoro)methyl]benzyl}malonic acid, benzyl methyl ester

Chemical Property:

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Technology Process of {4-[(di-tert-butoxyphosphoryl)(difluoro)methyl]benzyl}malonic acid, benzyl methyl ester

There total 1 articles about {4-[(di-tert-butoxyphosphoryl)(difluoro)methyl]benzyl}malonic acid, benzyl methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl methyl malonate (52267-39-7) + (4-bromomethylphenyl) difluoromethylphosphonic acid di-tert-butyl ester (261176-00-5) → {4-[(di-tert-butoxyphosphoryl)(difluoro)methyl]benzyl}malonic acid, benzyl methyl ester (345953-51-7)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2003.11.048

Reference yield:

1,1-dimethylethyl 2-(4-bromomethylphenyl)-2,2-difluoroacetate (127152-63-0) + {4-[(di-tert-butoxyphosphoryl)(difluoro)methyl]benzyl}malonic acid, benzyl methyl ester (345953-51-7) → 2-{4-[3-(benzyloxy)-2-{4-[difluoro(phosphono)methyl]benzyl}-2-(methoxycarbonyl)-3-oxopropyl]phenyl}-2,2-difluoroacetic acid (261175-13-7)

Guidance literature:

With NaH; trifluoroacetic acid; In water; N,N-dimethyl-formamide;

Reference yield:

benzyl methyl malonate (52267-39-7) + (4-bromomethylphenyl) difluoromethylphosphonic acid di-tert-butyl ester (261176-00-5) + {4-[(di-tert-butoxyphosphoryl)(difluoro)methyl]benzyl}malonic acid, benzyl methyl ester (345953-51-7) → 2,2-Di{4-[(di-tert-butoxyphosphoryl)(difluoro)methyl]benzyl}malonic Acid

Guidance literature:

With n-Bu₄NI; NaH; In N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

benzyl methyl malonate

(4-bromomethylphenyl) difluoromethylphosphonic acid di-tert-butyl ester

Downstream raw materials:

2,2-bis-{4-[(di-tert-butoxy-phosphoryl)-difluoro-methyl]-benzyl}-malonic acid benzyl ester methyl ester

2-{4-[3-(benzyloxy)-2-{4-[difluoro(phosphono)methyl]benzyl}-2-(methoxycarbonyl)-3-oxopropyl]phenyl}-2,2-difluoroacetic acid

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