1-[2-Hydroxy-4,6-diMethoxy-3-(MethoxyMethoxy)phenyl]-1-propanone

Base Information

Chemical Name:1-[2-Hydroxy-4,6-diMethoxy-3-(MethoxyMethoxy)phenyl]-1-propanone
CAS No.:276690-11-0
Molecular Formula:C₁₃H₁₈O₆
Molecular Weight:270.282
Hs Code.:
Mol file:276690-11-0.mol

Synonyms:1-[2-hydroxy-4,6-dimethoxy-3-(methoxymethoxy)phenyl]propan-1-one

Suppliers and Price of 1-[2-Hydroxy-4,6-diMethoxy-3-(MethoxyMethoxy)phenyl]-1-propanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-[2-Hydroxy-4,6-dimethoxy-3-(methoxymethoxy)phenyl]-1-propanone
10mg
$ 165.00

TRC
1-[2-Hydroxy-4,6-dimethoxy-3-(methoxymethoxy)phenyl]-1-propanone
100mg
$ 1320.00

Medical Isotopes, Inc.
1-[2-Hydroxy-4,6-dimethoxy-3-(methoxymethoxy)phenyl]-1-propanone
10 mg
$ 650.00

Total 1 raw suppliers

Chemical Property of 1-[2-Hydroxy-4,6-diMethoxy-3-(MethoxyMethoxy)phenyl]-1-propanone

Chemical Property:

Boiling Point:412.9±45.0 °C(Predicted)
PKA:6.65±0.50(Predicted)
Density:1.171±0.06 g/cm3(Predicted)
Solubility.:Dichloromethane, Ethyl Acetate

Purity/Quality:: 1-[2-Hydroxy-4,6-dimethoxy-3-(methoxymethoxy)phenyl]-1-propanone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 1-[2-Hydroxy-4,6-dimethoxy-3-(methoxymethoxy)phenyl]-1-propanone is a reactant used in the preparation of Stigmatellin A (S686780).

Technology Process of 1-[2-Hydroxy-4,6-diMethoxy-3-(MethoxyMethoxy)phenyl]-1-propanone

There total 7 articles about 1-[2-Hydroxy-4,6-diMethoxy-3-(MethoxyMethoxy)phenyl]-1-propanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 94190-89-3
1-(2,3-Dihydroxy-4,6-dimethoxyphenyl)propan-1-one

: 107-30-2
chloromethyl methyl ether

: 276690-11-0
1-[2-hydroxy-4,6-dimethoxy-3-(methoxymethoxy)phenyl]propan-1-one

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

Reference yield: 63.7%

: (4S,5S,6S,7R)-3,5-dimethoxy-2-(methoxymethoxy)-6-propionylphenyl-5,7-dimethoxy-4,6-dimethyl-8-[(triisopropylsilyl)oxy]octanoate

: (4S,5S,6S,7R)-5,7-dimethoxy-4,6-dimethyl-8-[(triisopropylsilyl)oxy]octanoic acid

: 2-[(3S,4S,5S,6R)-4,6-dimethoxy-3,5-dimethyl-7-{(triisopropylsilyl)oxy}heptyl]-5,7-dimethoxy-8-(methoxymethoxy)-3-methyl-4H-chromen-4-one

: 276690-11-0
1-[2-hydroxy-4,6-dimethoxy-3-(methoxymethoxy)phenyl]propan-1-one

Guidance literature:: With sodium; In methanol; for 2h; Inert atmosphere; Cooling with ice; Reflux;
DOI:10.1246/bcsj.20140271

Reference yield:

: 500-99-2
3,5-dimethoxyphenol

: 276690-11-0
1-[2-hydroxy-4,6-dimethoxy-3-(methoxymethoxy)phenyl]propan-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / P₄O₁₀; H₃PO₄ / 1 h / 70 °C

2: 87 percent / TFA; MCPBA / CH₂Cl₂ / 16 h / 0 - 5 °C

3: 99 percent / aq. HCl / methanol / 2 h / Heating

4: 98 percent / DIPEA / CH₂Cl₂ / 20 °C

With hydrogenchloride; phosphorus pentoxide; phosphoric acid; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In methanol; dichloromethane; 1: Acylation / 2: Baeyer-Villiger oxidation / 3: Hydrolysis / 4: Etherification;