Hexahydro-cyclopenta[c]pyrrole-1,2-dicarboxylic acid di-tert-butyl ester

Base Information

Chemical Name:Hexahydro-cyclopenta[c]pyrrole-1,2-dicarboxylic acid di-tert-butyl ester
CAS No.:402960-06-9
Molecular Formula:C17H29 N O4
Molecular Weight:311.422
Hs Code.:
Mol file:402960-06-9.mol

Synonyms:Cyclopenta[c]pyrrole-1,2(1H)-dicarboxylicacid, hexahydro-, bis(1,1-dimethylethyl) ester, (1S,3aR,6aS)- (9CI)

Suppliers and Price of Hexahydro-cyclopenta[c]pyrrole-1,2-dicarboxylic acid di-tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(1S,3aR,6aS)-Hexahydro-cyclopenta[c]pyrrole-1,2(1H)-dicarboxylicAcidBis(tert-butyl)Ester
1mg
$ 165.00

Medical Isotopes, Inc.
(1S,3aR,6aS)-Hexahydro-cyclopenta[c]pyrrole-1,2(1H)-dicarboxylicAcidBis(tert-butyl)Ester
1 mg
$ 650.00

Crysdot
(1S,3aR,6aS)-Di-tert-butylhexahydrocyclopenta[c]pyrrole-1,2(1H)-dicarboxylate 95+%
250mg
$ 378.00

Crysdot
(1S,3aR,6aS)-Di-tert-butylhexahydrocyclopenta[c]pyrrole-1,2(1H)-dicarboxylate 95+%
1g
$ 947.00

Chemenu
(1S,3aR,6aS)-Di-tert-butylhexahydrocyclopenta[c]pyrrole-1,2(1H)-dicarboxylate 95%
1g
$ 893.00

American Custom Chemicals Corporation
(1S,3AR,6AS)-HEXAHYDRO-CYCLOPENTA[C]PYRROLE-1,2(1H)-DICARBOXYLIC ACID BIS(TERT-BUTYL) ESTER 95.00%
5MG
$ 495.99

Alichem
(1S,3aR,6aS)-Di-tert-butylhexahydrocyclopenta[c]pyrrole-1,2(1H)-dicarboxylate
1g
$ 806.40

Total 20 raw suppliers

Chemical Property of Hexahydro-cyclopenta[c]pyrrole-1,2-dicarboxylic acid di-tert-butyl ester

Chemical Property:

PSA：55.84000
LogP:3.30160
Storage Temp.:2-8°C
Solubility.:Dichloromethane

Purity/Quality:

97% ^*data from raw suppliers

(1S,3aR,6aS)-Hexahydro-cyclopenta[c]pyrrole-1,2(1H)-dicarboxylicAcidBis(tert-butyl)Ester ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses (1S,3aR,6aS)-Hexahydro-cyclopenta[c]pyrrole-1,2(1H)-dicarboxylic Acid Bis(tert-butyl) Ester can be used in the preparation of peptidomimetic protease inhibitors.

Technology Process of Hexahydro-cyclopenta[c]pyrrole-1,2-dicarboxylic acid di-tert-butyl ester

There total 10 articles about Hexahydro-cyclopenta[c]pyrrole-1,2-dicarboxylic acid di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1451053-01-2
(R)-tert-butyl 2-(tert-butoxycarbonylamino)-2-(((1S,2R)-2-hydroxymethyl)cyclopentyl)acetate

: 402960-06-9
(1S,3aR,6aS)-di-tert-butyl hexahydrocyclo-penta[c]pyrrol-1,2(1H)-dicarboxylate

Guidance literature:: With 1H-imidazole; iodine; triphenylphosphine; In dichloromethane; at 0 - 20 ℃; for 12h; Inert atmosphere;

Reference yield:

: 1227704-10-0
(1S,3aR,6aS)-2-(tert-butoxycarbonyl)octahydrocyclopenta[c]pyrrole-1-carboxylic acid (S)-1,2,3,4-tetrahydro-1-naphthylammonium salt

: 24424-99-5
di-tert-butyl dicarbonate

: 402960-06-9
(1S,3aR,6aS)-di-tert-butyl hexahydrocyclo-penta[c]pyrrol-1,2(1H)-dicarboxylate

Guidance literature:: With dmap; In tert-butyl methyl ether; tert-butyl alcohol; at 22 - 27 ℃; for 6h; Industrial scale;
DOI:10.1021/op500040j

Reference yield:

: (RS,SR)-2-[(tert-butoxycarbonyl)amino]-2-(2-methylenecyclopentyl)acetic acid

: 402960-06-9
(1S,3aR,6aS)-di-tert-butyl hexahydrocyclo-penta[c]pyrrol-1,2(1H)-dicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: diethyl ether; toluene / 0.5 h / 20 °C

2.1: PROTEX 6L / aq. phosphate buffer; tert-butyl methyl ether / 24 h / 20 °C / pH 7.66 / Resolution of racemate; Enzymatic reaction

3.1: dmap / tert-butyl alcohol / 3 h / Inert atmosphere

4.1: borane-THF / tetrahydrofuran / 2 h / -25 - 0 °C / Inert atmosphere

4.2: 1 h / 0 °C

5.1: triphenylphosphine; iodine; 1H-imidazole / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; dmap; borane-THF; iodine; triphenylphosphine; In tetrahydrofuran; aq. phosphate buffer; diethyl ether; dichloromethane; tert-butyl methyl ether; toluene; tert-butyl alcohol;