1-(4-fluorophenyl)-3-(1-methylpiperidin-4-yl)-5-(pyrimidin-5-yl)-1H-indole

Base Information

Chemical Name:1-(4-fluorophenyl)-3-(1-methylpiperidin-4-yl)-5-(pyrimidin-5-yl)-1H-indole
CAS No.:1415089-60-9
Molecular Formula:C₂₄H₂₃FN₄
Molecular Weight:386.472
Hs Code.:

Synonyms:1-(4-fluorophenyl)-3-(1-methylpiperidin-4-yl)-5-(pyrimidin-5-yl)-1H-indole

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Chemical Property of 1-(4-fluorophenyl)-3-(1-methylpiperidin-4-yl)-5-(pyrimidin-5-yl)-1H-indole

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Technology Process of 1-(4-fluorophenyl)-3-(1-methylpiperidin-4-yl)-5-(pyrimidin-5-yl)-1H-indole

There total 4 articles about 1-(4-fluorophenyl)-3-(1-methylpiperidin-4-yl)-5-(pyrimidin-5-yl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 1415089-66-5
5-bromo-1-(4-fluorophenyl)-3-(1-methylpiperidin-4-yl)-1H-indole

: 109299-78-7
pyrimidine 5-boronic acid

: 1415089-60-9
1-(4-fluorophenyl)-3-(1-methylpiperidin-4-yl)-5-(pyrimidin-5-yl)-1H-indole

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In water; toluene; at 100 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2012.10.049

Reference yield:

: 5-bromo-1-(4-fluorophenyl)-3-(1-methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indole

: 1415089-60-9
1-(4-fluorophenyl)-3-(1-methylpiperidin-4-yl)-5-(pyrimidin-5-yl)-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

1: platinum(IV) oxide; hydrogen / acetic acid / 66 h / 2250.23 Torr

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / toluene; water / 100 °C / Inert atmosphere

With platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; sodium carbonate; In water; acetic acid; toluene; 2: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmc.2012.10.049

Reference yield:

: 138900-24-0
1-(4-fluorophenyl)-5-bromo-1H-indole

: 1415089-60-9
1-(4-fluorophenyl)-3-(1-methylpiperidin-4-yl)-5-(pyrimidin-5-yl)-1H-indole

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid; acetone / 3 h / Reflux

2: platinum(IV) oxide; hydrogen / acetic acid / 66 h / 2250.23 Torr

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / toluene; water / 100 °C / Inert atmosphere

With platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; sodium carbonate; In water; acetic acid; acetone; toluene; trifluoroacetic acid; 3: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmc.2012.10.049