2-benzyloxycarbonylamino-5-[2-(3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-propionylamino]-pentanoic acid

Base Information

Chemical Name:2-benzyloxycarbonylamino-5-[2-(3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-propionylamino]-pentanoic acid
CAS No.:913338-32-6
Molecular Formula:C₃₅H₅₀N₂O₆
Molecular Weight:594.792
Hs Code.:

2-benzyloxycarbonylamino-5-[2-(3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1<i>H</i>-cyclopenta[<i>a</i>]phenanthren-17-yl)-propionylamino]-pentanoic acid

Synonyms:2-benzyloxycarbonylamino-5-[2-(3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-propionylamino]-pentanoic acid

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Chemical Property of 2-benzyloxycarbonylamino-5-[2-(3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-propionylamino]-pentanoic acid

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Technology Process of 2-benzyloxycarbonylamino-5-[2-(3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-propionylamino]-pentanoic acid

There total 3 articles about 2-benzyloxycarbonylamino-5-[2-(3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-propionylamino]-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 913338-75-7
5-[2-(3-acetoxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-propionylamino]-2-benzyloxycarbonylamino-pentanoic acid

: 913338-32-6
2-benzyloxycarbonylamino-5-[2-(3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-propionylamino]-pentanoic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; at 50 ℃; for 24h;
DOI:10.1021/jm060290f

Reference yield:

: 2640-58-6
Nα-benzyloxycarbonyl-L-ornithine

: 913338-32-6
2-benzyloxycarbonylamino-5-[2-(3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-propionylamino]-pentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: HOBt; TBTU; DIPEA / dimethylformamide / 1 h

1.2: 55 percent / dimethylformamide

2.1: 30 percent / aq. LiOH / tetrahydrofuran / 24 h / 50 °C

With lithium hydroxide; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm060290f

Reference yield:

: 1474-14-2
3β-acetoxybisnor-5-cholenic acid

: 913338-32-6
2-benzyloxycarbonylamino-5-[2-(3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-propionylamino]-pentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: HOBt; TBTU; DIPEA / dimethylformamide / 1 h

1.2: 55 percent / dimethylformamide

2.1: 30 percent / aq. LiOH / tetrahydrofuran / 24 h / 50 °C

With lithium hydroxide; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm060290f