(S)-tert-butyl(1-(2-amino-4-(trifluoromethyl)phenoxy)-3,3-dimethylbutan-2-yl)carbamate

Base Information

• Chemical Name: (S)-tert-butyl(1-(2-amino-4-(trifluoromethyl)phenoxy)-3,3-dimethylbutan-2-yl)carbamate
• CAS No.: 1073176-43-8
• Molecular Formula: C₁₈H₂₇F₃N₂O₃
• Molecular Weight: 376.419

Synonyms:(S)-tert-butyl(1-(2-amino-4-(trifluoromethyl)phenoxy)-3,3-dimethylbutan-2-yl)carbamate

Chemical Property of (S)-tert-butyl(1-(2-amino-4-(trifluoromethyl)phenoxy)-3,3-dimethylbutan-2-yl)carbamate

Chemical Property:

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Technology Process of (S)-tert-butyl(1-(2-amino-4-(trifluoromethyl)phenoxy)-3,3-dimethylbutan-2-yl)carbamate

There total 3 articles about (S)-tert-butyl(1-(2-amino-4-(trifluoromethyl)phenoxy)-3,3-dimethylbutan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(S)-tert-butyl(3,3-dimethyl-1-(2-nitro-4-(trifluoromethyl)phenoxy)butan-2-yl)carbamate (1073176-30-3) → (S)-tert-butyl(1-(2-amino-4-(trifluoromethyl)phenoxy)-3,3-dimethylbutan-2-yl)carbamate (1073176-43-8)

Guidance literature:

With palladium 10% on activated carbon; ammonium formate; In methanol; ethyl acetate; for 0.333333h;

DOI:10.1002/chem.201602905

Reference yield:

N-Boc-L-tert-leucinol (153645-26-2,545433-63-4) → (S)-tert-butyl(1-(2-amino-4-(trifluoromethyl)phenoxy)-3,3-dimethylbutan-2-yl)carbamate (1073176-43-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hexamethylsilazane / tetrahydrofuran / 1.5 h / 0 °C

2: ammonium formate; palladium 10% on activated carbon / ethyl acetate; methanol / 0.33 h

With palladium 10% on activated carbon; ammonium formate; potassium hexamethylsilazane; In tetrahydrofuran; methanol; ethyl acetate;

DOI:10.1002/chem.201602905

Reference yield:

1-fluoro-2-nitro-4-trifluoromethyl-benzene (367-86-2) → (S)-tert-butyl(1-(2-amino-4-(trifluoromethyl)phenoxy)-3,3-dimethylbutan-2-yl)carbamate (1073176-43-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hexamethylsilazane / tetrahydrofuran / 1.5 h / 0 °C

2: ammonium formate; palladium 10% on activated carbon / ethyl acetate; methanol / 0.33 h

With palladium 10% on activated carbon; ammonium formate; potassium hexamethylsilazane; In tetrahydrofuran; methanol; ethyl acetate;

DOI:10.1002/chem.201602905

upstream raw materials:

(S)-tert-butyl(3,3-dimethyl-1-(2-nitro-4-(trifluoromethyl)phenoxy)butan-2-yl)carbamate

1-fluoro-2-nitro-4-trifluoromethyl-benzene

N-Boc-L-tert-leucinol

Downstream raw materials:

(S)-tert-butyl 1-(2-ethanamido-4-(trifluoromethyl)phenoxy)-3,3-dimethylbutan-2-ylcarbamate

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