Methyl 7-bromo-3-(3,4-difluorophenyl)-6-(methyloxy)-5-quinoxalinecarboxylate

Base Information

Chemical Name:Methyl 7-bromo-3-(3,4-difluorophenyl)-6-(methyloxy)-5-quinoxalinecarboxylate
CAS No.:1160682-79-0
Molecular Formula:C₁₇H₁₁BrF₂N₂O₃
Molecular Weight:409.187
Hs Code.:

Synonyms:Methyl 7-bromo-3-(3,4-difluorophenyl)-6-(methyloxy)-5-quinoxalinecarboxylate

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Chemical Property of Methyl 7-bromo-3-(3,4-difluorophenyl)-6-(methyloxy)-5-quinoxalinecarboxylate

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Technology Process of Methyl 7-bromo-3-(3,4-difluorophenyl)-6-(methyloxy)-5-quinoxalinecarboxylate

There total 5 articles about Methyl 7-bromo-3-(3,4-difluorophenyl)-6-(methyloxy)-5-quinoxalinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1160682-52-9
methyl 2-amino-5-bromo-6-(methyloxy)-3-nitrobenzoate

: 79784-34-2
3,4-difluorophenylglyoxal

: 1160682-79-0
Methyl 7-bromo-3-(3,4-difluorophenyl)-6-(methyloxy)-5-quinoxalinecarboxylate

Guidance literature:: methyl 2-amino-5-bromo-6-(methyloxy)-3-nitrobenzoate; With hydrogen; palladium 10% on activated carbon; In ethyl acetate; at 20 ℃; for 2h; under 760.051 Torr;

3,4-difluorophenylglyoxal; In methanol; at 100 ℃; for 0.333333h; Product distribution / selectivity; Microwave irradiation;

Reference yield:

: 13671-00-6
methyl 2,6-difluorobenzoate

: 1160682-79-0
Methyl 7-bromo-3-(3,4-difluorophenyl)-6-(methyloxy)-5-quinoxalinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid; nitric acid / 0 - 20 °C

2.1: ammonium hydroxide / ethanol; water / 20 °C

3.1: sodium hydride / mineral oil / 1 h / 0 - 20 °C

4.1: bromine / dichloromethane / 0.5 h / 20 °C

5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2 h / 20 °C / 760.05 Torr

5.2: 0.33 h / 100 °C / Microwave irradiation

With ammonium hydroxide; sulfuric acid; hydrogen; bromine; nitric acid; sodium hydride; palladium 10% on activated carbon; In ethanol; dichloromethane; water; ethyl acetate; mineral oil;

Reference yield:

: 346691-23-4
methyl 2-amino-6-fluoro-3-nitrobenzoate

: 1160682-79-0
Methyl 7-bromo-3-(3,4-difluorophenyl)-6-(methyloxy)-5-quinoxalinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / mineral oil / 1 h / 0 - 20 °C

2.1: bromine / dichloromethane / 0.5 h / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2 h / 20 °C / 760.05 Torr

3.2: 0.33 h / 100 °C / Microwave irradiation

With hydrogen; bromine; sodium hydride; palladium 10% on activated carbon; In dichloromethane; ethyl acetate; mineral oil;