4-[((2S)-2-[5-(methoxycarbonyl)-1H-imidazol-1-yl]methyl-5-oxotetrahydro-1H-pyrrol-1-yl)methyl]benzenecarboxylic acid

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Chemical Name:4-[((2S)-2-[5-(methoxycarbonyl)-1H-imidazol-1-yl]methyl-5-oxotetrahydro-1H-pyrrol-1-yl)methyl]benzenecarboxylic acid
CAS No.:1308719-77-8
Molecular Formula:C₁₈H₁₉N₃O₅
Molecular Weight:357.366
Hs Code.:

Synonyms:4-[((2S)-2-[5-(methoxycarbonyl)-1H-imidazol-1-yl]methyl-5-oxotetrahydro-1H-pyrrol-1-yl)methyl]benzenecarboxylic acid

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Chemical Property of 4-[((2S)-2-[5-(methoxycarbonyl)-1H-imidazol-1-yl]methyl-5-oxotetrahydro-1H-pyrrol-1-yl)methyl]benzenecarboxylic acid

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Technology Process of 4-[((2S)-2-[5-(methoxycarbonyl)-1H-imidazol-1-yl]methyl-5-oxotetrahydro-1H-pyrrol-1-yl)methyl]benzenecarboxylic acid

There total 10 articles about 4-[((2S)-2-[5-(methoxycarbonyl)-1H-imidazol-1-yl]methyl-5-oxotetrahydro-1H-pyrrol-1-yl)methyl]benzenecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1308719-69-8
methyl 1-[((2S)-1-4-[(benzyloxy)carbonyl]benzyl-5-oxotetrahydro-1H-pyrrol-2-yl)methyl]-1H-imidazole-5-carboxylate

: 1308719-77-8
4-[((2S)-2-[5-(methoxycarbonyl)-1H-imidazol-1-yl]methyl-5-oxotetrahydro-1H-pyrrol-1-yl)methyl]benzenecarboxylic acid

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol;
DOI:10.1016/j.bmc.2011.03.044

Reference yield:

: 17342-08-4
(S)-Pyroglutaminol

: 1308719-77-8
4-[((2S)-2-[5-(methoxycarbonyl)-1H-imidazol-1-yl]methyl-5-oxotetrahydro-1H-pyrrol-1-yl)methyl]benzenecarboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: dmap; triethylamine / N,N-dimethyl-formamide / 2.5 h / 20 °C

2.1: sodium hydride / tetrahydrofuran; paraffin oil / 0 - 20 °C

3.1: trifluoroacetic acid / dichloromethane / 0.17 h / 20 °C

4.1: triethylamine / dichloromethane / 0 - 20 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 50 °C / Inert atmosphere

5.2: 50 °C / Inert atmosphere

6.1: palladium 10% on activated carbon; hydrogen / methanol

With dmap; palladium 10% on activated carbon; hydrogen; sodium hydride; caesium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; paraffin oil;
DOI:10.1016/j.bmc.2011.03.044

Reference yield:

: 1308719-52-9
4-[[2-oxo-(5S)-[[(triethylsilyl)oxy]methyl]-1-pyrrolidinyl]methyl]benzoic acid phenylmethyl ester

: 1308719-77-8
4-[((2S)-2-[5-(methoxycarbonyl)-1H-imidazol-1-yl]methyl-5-oxotetrahydro-1H-pyrrol-1-yl)methyl]benzenecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / dichloromethane / 0.17 h / 20 °C

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 50 °C / Inert atmosphere

3.2: 50 °C / Inert atmosphere

4.1: palladium 10% on activated carbon; hydrogen / methanol

With palladium 10% on activated carbon; hydrogen; caesium carbonate; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.03.044