tert-butyl (1'-benzylspiro[indoline-3,4'-piperidine]-4-yl)methylcarbamate

Base Information

• Chemical Name: tert-butyl (1'-benzylspiro[indoline-3,4'-piperidine]-4-yl)methylcarbamate
• CAS No.: 1172588-56-5
• Molecular Formula: C₂₅H₃₃N₃O₂
• Molecular Weight: 407.556
• Mol file: 1172588-56-5.mol

Synonyms:tert-butyl (1'-benzylspiro[indoline-3,4'-piperidine]-4-yl)methylcarbamate

Chemical Property of tert-butyl (1'-benzylspiro[indoline-3,4'-piperidine]-4-yl)methylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (1'-benzylspiro[indoline-3,4'-piperidine]-4-yl)methylcarbamate

There total 1 articles about tert-butyl (1'-benzylspiro[indoline-3,4'-piperidine]-4-yl)methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

di-tert-butyl dicarbonate (24424-99-5) + (1'-benzylspiro[indoline-3,4'-piperidine]-4-yl)methanamine (1172588-55-4) → tert-butyl (1'-benzylspiro[indoline-3,4'-piperidine]-4-yl)methylcarbamate (1172588-56-5)

Guidance literature:

di-tert-butyl dicarbonate; (1'-benzylspiro[indoline-3,4'-piperidine]-4-yl)methanamine; In dichloromethane; at 0 ℃; for 4h;

With methylamine; In methanol; dichloromethane; for 1h; Product distribution / selectivity;

Reference yield: 75.7%

(R)-4-chloro-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine (953045-35-7) + tert-butyl (1'-benzylspiro[indoline-3,4'-piperidine]-4-yl)methylcarbamate (1172588-56-5) → (R)-tert-butyl (1'-benzyl-1-(5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)spiro[indoline-3,4'-piperidine]-4-yl)methylcarbamate (1172588-72-5)

Guidance literature:

With caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate; In toluene; at 100 ℃; for 4h; Product distribution / selectivity;

Reference yield: 70.0%

4-chloro-5-ethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine (1172589-14-8) + tert-butyl (1'-benzylspiro[indoline-3,4'-piperidine]-4-yl)methylcarbamate (1172588-56-5) → tert-butyl (1'-benzyl-1-(5-ethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)spiro[indoline-3,4'-piperidine]-4-yl)methylcarbamate (1172589-15-9)

Guidance literature:

With caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate; In toluene; at 95 ℃; for 24h;

upstream raw materials:

di-tert-butyl dicarbonate

(1'-benzylspiro[indoline-3,4'-piperidine]-4-yl)methanamine

Downstream raw materials:

tert-butyl 1'-benzyl-4-((tert-butoxycarbonylamino)methyl)spiro[indoline-3,4'-piperidine]-1-carboxylate

(R)-tert-butyl (1'-benzyl-1-(5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)spiro[indoline-3,4'-piperidine]-4-yl)methylcarbamate

tert-butyl (1'-benzyl-1-(5-ethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)spiro[indoline-3,4'-piperidine]-4-yl)methylcarbamate

tert-butyl (1'-benzyl-1-(5-isopropyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)spiro[indoline-3,4'-piperidine]-4-yl)methylcarbamate