1H-Pyrrolo[2,3-b]pyridine, 6-chloro-4-nitro-1-[[2-(triMethylsilyl)ethoxy]Methyl]-

Base Information

• Chemical Name: 1H-Pyrrolo[2,3-b]pyridine, 6-chloro-4-nitro-1-[[2-(triMethylsilyl)ethoxy]Methyl]-
• CAS No.: 869335-22-8
• Molecular Formula: C13H18 Cl N3 O3 Si
• Molecular Weight: 327.843
• Hs Code.: 2933990090
• Mol file: 869335-22-8.mol

Synonyms:6-Chloro-4-nitro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine;

Chemical Property of 1H-Pyrrolo[2,3-b]pyridine, 6-chloro-4-nitro-1-[[2-(triMethylsilyl)ethoxy]Methyl]-

Chemical Property:

• Boiling Point: 420.7±45.0 °C(Predicted)
• PKA: -2.14±0.30(Predicted)
• PSA: 72.87000
• Density: 1.26±0.1 g/cm3(Predicted)
• LogP: 4.43340
• Storage Temp.: 2-8°C

Purity/Quality:

>98% ^*data from raw suppliers

6-Chloro-4-nitro-1-((2-(trimethylsilyl)ethoxy)-methyl)-1H-pyrrolo[2,3-b]pyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrolo[2,3-b]pyridine, 6-chloro-4-nitro-1-[[2-(triMethylsilyl)ethoxy]Methyl]-

There total 3 articles about 1H-Pyrrolo[2,3-b]pyridine, 6-chloro-4-nitro-1-[[2-(triMethylsilyl)ethoxy]Methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

6-chloro-4-nitro-1H-pyrrolo[2,3-b]pyridine (688781-87-5) + (2-trimethylethylsilylethoxy)methyl chloride (76513-69-4) → 6-chloro-4-nitro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine (869335-22-8)

Guidance literature:

6-chloro-4-nitro-1H-pyrrolo[2,3-b]pyridine; With sodium hydride; In DMF (N,N-dimethyl-formamide); at 0 ℃; for 0.5h;

(2-trimethylethylsilylethoxy)methyl chloride; In DMF (N,N-dimethyl-formamide); at 0 - 20 ℃; for 2h;

Reference yield:

4-nitro-1H-pyrrolo<2,3-b>pyridine 7-oxide (74420-06-7) → 6-chloro-4-nitro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine (869335-22-8)

Guidance literature:

Multi-step reaction with 2 steps

1: Cl₃CCOCl; (Me₃Si)2NH / tetrahydrofuran / 1 h

2: 65 percent / NaH / tetrahydrofuran / 1 h

With sodium hydride; 1,1,1,3,3,3-hexamethyl-disilazane; trifluoroacetyl chloride; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2006.01.143

Reference yield:

→ 6-chloro-4-nitro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine (869335-22-8)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; for 1h; Inert atmosphere; Cooling with ice;

In N,N-dimethyl-formamide; mineral oil; for 0.5h;

upstream raw materials:

6-chloro-4-nitro-1H-pyrrolo[2,3-b]pyridine

(2-trimethylethylsilylethoxy)methyl chloride

4-nitro-1H-pyrrolo<2,3-b>pyridine 7-oxide

Downstream raw materials:

4-[6-chloro-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrolo[2,3-b]pyridin-4-yloxy]-3-fluoro-phenylamine

3-fluoro-4-((1H-pyrrolo [2,3-b]pyridin-4-yl)oxy)aniline

3-fluoro-4-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrolo[2,3-b]pyridin-4-yloxy]-phenylamine

C₁₉H₂₂ClF₂N₃O₂Si

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 869335-22-8 1H-Pyrrolo[2,3-b]pyridine, 6-chloro-4-nitro-1-[[2-(triMethylsilyl)ethoxy]Methyl]-

Send

Send

Metric Ton KG G Pound L ML

Send

Send