1-N-(3-(N'-(tert-butoxycarbonyl)amino)benzyl)-3-(3-phenylthioureido)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one

Base Information

Chemical Name:1-N-(3-(N'-(tert-butoxycarbonyl)amino)benzyl)-3-(3-phenylthioureido)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one
CAS No.:247152-86-9
Molecular Formula:C₂₉H₃₂N₄O₃S
Molecular Weight:516.664
Hs Code.:

Synonyms:1-N-(3-(N'-(tert-butoxycarbonyl)amino)benzyl)-3-(3-phenylthioureido)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one

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Chemical Property of 1-N-(3-(N'-(tert-butoxycarbonyl)amino)benzyl)-3-(3-phenylthioureido)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one

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Technology Process of 1-N-(3-(N'-(tert-butoxycarbonyl)amino)benzyl)-3-(3-phenylthioureido)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one

There total 6 articles about 1-N-(3-(N'-(tert-butoxycarbonyl)amino)benzyl)-3-(3-phenylthioureido)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 103-72-0
phenyl isothiocyanate

: 239097-32-6
3-amino-1-N-(3-(N'-(tert-butoxycarbonyl)amino)benzyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one

: 247152-86-9
1-N-(3-(N'-(tert-butoxycarbonyl)amino)benzyl)-3-(3-phenylthioureido)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one

Guidance literature:: In acetonitrile; at 20 ℃; for 1h;
DOI:10.1016/S0968-0896(99)00087-5

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 247152-86-9
1-N-(3-(N'-(tert-butoxycarbonyl)amino)benzyl)-3-(3-phenylthioureido)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent

2: 71 percent / Ph₃P; NBS / CH₂Cl₂ / 2 h

3: 96 percent / tetrabutylammonium bromide; KOH / tetrahydrofuran / 2 h / 20 °C

4: 100 percent / hydrogen / Pd/C / methanol / 20 °C

5: 68 percent / acetonitrile / 1 h / 20 °C

With potassium hydroxide; N-Bromosuccinimide; tetrabutylammomium bromide; hydrogen; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; acetonitrile; 1: Acylation / 2: Bromination / 3: Alkylation / 4: Catalytic hydrogenation / 5: Addition;
DOI:10.1016/S0968-0896(99)00087-5

Reference yield:

: 1877-77-6
3-aminobenzenemethanol

: 247152-86-9
1-N-(3-(N'-(tert-butoxycarbonyl)amino)benzyl)-3-(3-phenylthioureido)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent

2: 71 percent / Ph₃P; NBS / CH₂Cl₂ / 2 h

3: 96 percent / tetrabutylammonium bromide; KOH / tetrahydrofuran / 2 h / 20 °C

4: 100 percent / hydrogen / Pd/C / methanol / 20 °C

5: 68 percent / acetonitrile / 1 h / 20 °C

With potassium hydroxide; N-Bromosuccinimide; tetrabutylammomium bromide; hydrogen; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; acetonitrile; 1: Acylation / 2: Bromination / 3: Alkylation / 4: Catalytic hydrogenation / 5: Addition;
DOI:10.1016/S0968-0896(99)00087-5