C₄₂H₅₄N₄O₉

Base Information

• Chemical Name: C₄₂H₅₄N₄O₉
• CAS No.: 1334511-77-1
• Molecular Formula: C₄₂H₅₄N₄O₉
• Molecular Weight: 758.912
• Mol file: 1334511-77-1.mol

Synonyms:C₄₂H₅₄N₄O₉

Chemical Property of C₄₂H₅₄N₄O₉

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₂H₅₄N₄O₉

There total 9 articles about C₄₂H₅₄N₄O₉ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-4'-hydroxybiphenyl (29558-77-8) → C42H54N4O9 (1334511-77-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium carbonate / butanone / 8 h / Reflux

2.1: n-butyllithium / tert-butyl methyl ether / 2 h / -20 °C / Inert atmosphere

2.2: -60 - 20 °C

2.3: 0.17 h / 20 °C

3.1: palladium diacetate; sodium carbonate; triphenylphosphine / propan-1-ol; toluene / 4 h / Reflux; Inert atmosphere

4.1: cetyltrimethylammonim bromide; potassium hydroxide / 5,5-dimethyl-1,3-cyclohexadiene / 3 h / Reflux

4.2: 0.5 h / pH 1 / Reflux

5.1: dmap; benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane / 48 h / 20 °C

5.2: 48 h / 20 °C

With dmap; n-butyllithium; cetyltrimethylammonim bromide; palladium diacetate; sodium carbonate; potassium carbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; triphenylphosphine; potassium hydroxide; In propan-1-ol; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; tert-butyl methyl ether; toluene; butanone; 3.1: Suzuki reaction;

DOI:10.1016/j.ejmech.2012.01.054

Reference yield:

C20H36N4O7 + C22H20O3 (1315480-27-3) → C42H54N4O9 (1334511-77-1)

Guidance literature:

C₂₂H₂₀O₃; With dmap; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 48h;

C₂₀H₃₆N₄O₇; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

DOI:10.1016/j.ejmech.2012.01.054

Reference yield:

Nδ-Boc-Orn(Nα-Fmoc)-Thr-Pro-OMe (1203557-40-7) → C42H54N4O9 (1334511-77-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: diethylamine / dichloromethane / 2 h / Cooling with ice

2.1: dmap; benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane / 48 h / 20 °C

2.2: 48 h / 20 °C

With dmap; benzotriazol-1-ol; diethylamine; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1016/j.ejmech.2012.01.054

upstream raw materials:

(4'-propoxy-[1,1'-biphenyl]-4-yl)boronic acid

Nδ-Boc-Orn(Nα-Fmoc)-Thr-Pro-OMe

C₂₂H₂₀O₃

C₂₃H₂₂O₃

Downstream raw materials:

C₃₇H₄₆N₄O₇