Technology Process of 2-(5-hydroxyamidinobenzoxazol-2-yl)-5-(4-hydroxyamidinophenyl)furan
There total 4 articles about 2-(5-hydroxyamidinobenzoxazol-2-yl)-5-(4-hydroxyamidinophenyl)furan which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydroxylamine hydrochloride; potassium tert-butylate;
In
dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 80 percent / Pd(PPh3)4 / dioxane / 100 °C
2: 92 percent / NBS / dimethylformamide / 20 °C
3: 64 percent / Pd(PPh3)4; Na2CO3 / toluene; H2O; methanol / 80 °C
4: 100 percent / NH2OH*HCl; KO-t-Bu / dimethylsulfoxide
With
N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium(0); hydroxylamine hydrochloride; potassium tert-butylate; sodium carbonate;
In
1,4-dioxane; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
1: Stille coupling / 3: Suzuki coupling;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 92 percent / NBS / dimethylformamide / 20 °C
2: 64 percent / Pd(PPh3)4; Na2CO3 / toluene; H2O; methanol / 80 °C
3: 100 percent / NH2OH*HCl; KO-t-Bu / dimethylsulfoxide
With
N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium(0); hydroxylamine hydrochloride; potassium tert-butylate; sodium carbonate;
In
methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
2: Suzuki coupling;