2-[1-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-meth-(E)-ylidene]-3-thiophen-2-yl-heptanoic acid methyl ester

Base Information

Chemical Name:2-[1-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-meth-(E)-ylidene]-3-thiophen-2-yl-heptanoic acid methyl ester
CAS No.:1026273-52-8
Molecular Formula:C₂₇H₃₃ClN₂O₂S
Molecular Weight:485.09
Hs Code.:

Synonyms:2-[1-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-meth-(E)-ylidene]-3-thiophen-2-yl-heptanoic acid methyl ester

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Chemical Property of 2-[1-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-meth-(E)-ylidene]-3-thiophen-2-yl-heptanoic acid methyl ester

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Technology Process of 2-[1-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-meth-(E)-ylidene]-3-thiophen-2-yl-heptanoic acid methyl ester

There total 12 articles about 2-[1-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-meth-(E)-ylidene]-3-thiophen-2-yl-heptanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-{Acetoxy-[2-butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-methyl}-3-thiophen-2-yl-heptanoic acid methyl ester

: 1026273-52-8
2-[1-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-meth-(E)-ylidene]-3-thiophen-2-yl-heptanoic acid methyl ester

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene; at 100 ℃; for 1h; Yield given;
DOI:10.1021/jm00099a013

Reference yield:

: 17849-38-6
2-Chlorobenzyl alcohol

: 1026273-52-8
2-[1-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-meth-(E)-ylidene]-3-thiophen-2-yl-heptanoic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: diisopropylethylamine / CH₂Cl₂ / 0.33 h / -78 °C

2: CH₂Cl₂ / 18 h / Ambient temperature

3: 10percent aq. NaOH / methanol / 4 h / Heating

4: 93 percent / MnO₂ / CH₂Cl₂ / 19 h / Ambient temperature

5: 1.) LDA / 1.) THF, hexane, -78 deg C, 60 min, 2.) THF, hexane, -78 deg C, 10 min

6: (dimethylamino)pyridine / CH₂Cl₂ / 16 h

7: DBU / toluene / 1 h / 100 °C

With dmap; manganese(IV) oxide; sodium hydroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In methanol; dichloromethane; toluene;
DOI:10.1021/jm00099a013

Reference yield:

: 1124-65-8,15690-25-2,51019-83-1
3-(2-thienyl)-2-propenoic acid

: 1026273-52-8
2-[1-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-meth-(E)-ylidene]-3-thiophen-2-yl-heptanoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / HCl / diethyl ether / 23 h / 20 - 50 °C

2: 1.) CuCN / 1.) ether, hexane, -25 deg C, 20 min, 2.) ether, hexane, a) -78 deg C, 40 min, b) -25 deg C, 60 min

3: 1.) LDA / 1.) THF, hexane, -78 deg C, 60 min, 2.) THF, hexane, -78 deg C, 10 min

4: (dimethylamino)pyridine / CH₂Cl₂ / 16 h

5: DBU / toluene / 1 h / 100 °C

With hydrogenchloride; dmap; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium diisopropyl amide; In diethyl ether; dichloromethane; toluene;
DOI:10.1021/jm00099a013