2-AMINO-4,5-DIMETHYLTHIOPHENE-3-CARBOXAMIDE

Base Information

• Chemical Name: 2-AMINO-4,5-DIMETHYLTHIOPHENE-3-CARBOXAMIDE
• CAS No.: 51486-04-5
• Molecular Formula: C7H10N2OS
• Molecular Weight: 170.235
• Hs Code.: 2934999090
• Mol file: 51486-04-5.mol

Synonyms:2-Amino-4,5-dimethylthiophene-3-carboxamide;

Chemical Property of 2-AMINO-4,5-DIMETHYLTHIOPHENE-3-CARBOXAMIDE

Chemical Property:

• Vapor Pressure: 0.0197mmHg at 25°C
• Refractive Index: 1.635
• Boiling Point: 252.1 °C at 760 mmHg
• Flash Point: 106.3 °C
• PSA: 97.35000
• Density: 1.285 g/cm³
• LogP: 2.32750

Purity/Quality:

98%Min ^*data from raw suppliers

2-Amino-4,5-dimethylthiophene-3-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-4,5-DIMETHYLTHIOPHENE-3-CARBOXAMIDE

There total 3 articles about 2-AMINO-4,5-DIMETHYLTHIOPHENE-3-CARBOXAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-amino-4,5-dimethylthiophene-3-carbonitrile (4651-94-9) → 2-amino-4,5-dimethylthiophene-3-carboxamide (51486-04-5)

Guidance literature:

With sulfuric acid; water; at 65 - 70 ℃; for 2h;

DOI:10.3184/030823409X12537299044500

Reference yield: 20.0%

butanone (78-93-3) + cyanoacetic acid amide (107-91-5) → 2-amino-4,5-dimethylthiophene-3-carboxamide (51486-04-5)

Guidance literature:

With sulfur; diethylamine; In ethanol; at 20 ℃;

DOI:10.1021/jm400405z

Reference yield:

→ 2-amino-4,5-dimethylthiophene-3-carboxamide (51486-04-5)

Guidance literature:

Methylaethylketon, Cyanacetamid, S;

DOI:10.1007/BF00909644

upstream raw materials:

2-amino-4,5-dimethylthiophene-3-carbonitrile

butanone

cyanoacetic acid amide

Downstream raw materials:

4,5-dimethyl-2-(2-(naphthalen-1-yl)acetamido)thiophene-3-carboxamide

5,6-dimethylthieno<2,3-d>pyrimidin-4(3H)-one

5,6-dimethyl-2-(2,4,5-trihydroxyphenyl)thieno[2,3-d]pyrimidin-4(3H)-one

5,6-dimethyl-2-(3,4,5-trihydroxyphenyl)thieno[2,3-d]pyrimidin-4(3H)-one

Refernces

• 1、 Masaoka, Takashi,Chung, Suhman,Caboni, Pierluigi,Rausch, Jason W.,Wilson, Jennifer A.,Taskent-Sezgin, Humeyra,Beutler, John A.,Tocco, Graziella,Le Grice, Stuart F. J.. "Exploiting drug-resistant enzymes as tools to identify thienopyrimidinone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H". supporting information. p. 5436 - 5445. Retrieved 2013/07/26.
• 2、 Bakavoli, Mehdi,Bagherzadeh, Ghodsieh,Vaseghifar, Maryam,Shiri, Ali,Pordeli, Parvaneh. "Iodine catalysed synthesis and antibacterial evaluation of thieno-[2,3-d]pyrimidine derivatives". experimental part. p. 653 - 655. Retrieved 2010/03/24.