[4-(1,9-Dithia-5,13-diaza-cyclohexadec-5-ylmethyl)-phenyl]-(1,4,8,11-tetraaza-cyclotetradec-1-yl)-methanone

Base Information

Chemical Name:[4-(1,9-Dithia-5,13-diaza-cyclohexadec-5-ylmethyl)-phenyl]-(1,4,8,11-tetraaza-cyclotetradec-1-yl)-methanone
CAS No.:321658-95-1
Molecular Formula:C₃₀H₅₄N₆OS₂
Molecular Weight:578.93
Hs Code.:

Synonyms:[4-(1,9-Dithia-5,13-diaza-cyclohexadec-5-ylmethyl)-phenyl]-(1,4,8,11-tetraaza-cyclotetradec-1-yl)-methanone

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Chemical Property of [4-(1,9-Dithia-5,13-diaza-cyclohexadec-5-ylmethyl)-phenyl]-(1,4,8,11-tetraaza-cyclotetradec-1-yl)-methanone

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Technology Process of [4-(1,9-Dithia-5,13-diaza-cyclohexadec-5-ylmethyl)-phenyl]-(1,4,8,11-tetraaza-cyclotetradec-1-yl)-methanone

There total 4 articles about [4-(1,9-Dithia-5,13-diaza-cyclohexadec-5-ylmethyl)-phenyl]-(1,4,8,11-tetraaza-cyclotetradec-1-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 321658-94-0
11-[4-(13-tert-butoxycarbonyl-1,9-dithia-5,13-diaza-cyclohexadec-5-ylmethyl)-benzoyl]-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester

: 321658-95-1
[4-(1,9-Dithia-5,13-diaza-cyclohexadec-5-ylmethyl)-phenyl]-(1,4,8,11-tetraaza-cyclotetradec-1-yl)-methanone

Guidance literature:: With methyl-phenyl-thioether; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1039/b004797j

Reference yield:

: 876-08-4
p-(chloromethyl)benzoyl chloride

: 321658-95-1
[4-(1,9-Dithia-5,13-diaza-cyclohexadec-5-ylmethyl)-phenyl]-(1,4,8,11-tetraaza-cyclotetradec-1-yl)-methanone

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / Et₃N / CH₂Cl₂ / 1 h / 20 °C

2: 75 percent / sodium carbonate; sodium iodide / acetonitrile / 24 h / Heating

3: 71 percent / TFA; thioanisole / CH₂Cl₂ / 2 h / 20 °C

With methyl-phenyl-thioether; sodium carbonate; triethylamine; trifluoroacetic acid; sodium iodide; In dichloromethane; acetonitrile;
DOI:10.1039/b004797j

Reference yield:

: 170161-27-0
1,4,8-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane

: 321658-95-1
[4-(1,9-Dithia-5,13-diaza-cyclohexadec-5-ylmethyl)-phenyl]-(1,4,8,11-tetraaza-cyclotetradec-1-yl)-methanone

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / Et₃N / CH₂Cl₂ / 1 h / 20 °C

2: 75 percent / sodium carbonate; sodium iodide / acetonitrile / 24 h / Heating

3: 71 percent / TFA; thioanisole / CH₂Cl₂ / 2 h / 20 °C

With methyl-phenyl-thioether; sodium carbonate; triethylamine; trifluoroacetic acid; sodium iodide; In dichloromethane; acetonitrile;
DOI:10.1039/b004797j