methyl 2-bromo-3-[4-nitro-1-(phenylsulfonyl)-1H-indol-3-yl]prop-2-enoate

Base Information

Chemical Name:methyl 2-bromo-3-[4-nitro-1-(phenylsulfonyl)-1H-indol-3-yl]prop-2-enoate
CAS No.:1414703-82-4
Molecular Formula:C₁₈H₁₃BrN₂O₆S
Molecular Weight:465.281
Hs Code.:

Synonyms:methyl 2-bromo-3-[4-nitro-1-(phenylsulfonyl)-1H-indol-3-yl]prop-2-enoate

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Chemical Property of methyl 2-bromo-3-[4-nitro-1-(phenylsulfonyl)-1H-indol-3-yl]prop-2-enoate

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Technology Process of methyl 2-bromo-3-[4-nitro-1-(phenylsulfonyl)-1H-indol-3-yl]prop-2-enoate

There total 1 articles about methyl 2-bromo-3-[4-nitro-1-(phenylsulfonyl)-1H-indol-3-yl]prop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1414703-81-3
4-nitro-1-(phenylsulfonyl)-1H-indole-3-carbaldehyde

: 21204-67-1,2605-67-6
methyl (triphenylphosphoranylidene)acetate

: 1414703-82-4
methyl 2-bromo-3-[4-nitro-1-(phenylsulfonyl)-1H-indol-3-yl]prop-2-enoate

Guidance literature:: methyl (triphenylphosphoranylidene)acetate; With N-Bromosuccinimide; In dichloromethane; at -20 ℃; for 0.75h; Inert atmosphere;

4-nitro-1-(phenylsulfonyl)-1H-indole-3-carbaldehyde; With potassium carbonate; In dichloromethane; at -20 - 20 ℃; for 48h;
DOI:10.1016/j.ejmech.2012.08.029

Reference yield: 90.0%

: 1414703-82-4
methyl 2-bromo-3-[4-nitro-1-(phenylsulfonyl)-1H-indol-3-yl]prop-2-enoate

: 1414703-85-7
methyl 3-[4-amino-1-(phenylsulfonyl)-1H-indol-3-yl]-2-bromoprop-2-enoate

Guidance literature:: With iron; ammonium chloride; In water; isopropyl alcohol; at 60 ℃; for 2h;
DOI:10.1016/j.ejmech.2012.08.029

Reference yield:

: 1414703-82-4
methyl 2-bromo-3-[4-nitro-1-(phenylsulfonyl)-1H-indol-3-yl]prop-2-enoate

: methyl 6-(2,6-diaminophenyl)-1H-indole-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: iron; ammonium chloride / isopropyl alcohol; water / 2 h / 60 °C

2: dmap / dichloromethane / 48 h / 20 °C / Inert atmosphere

3: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 70 °C / Inert atmosphere

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 2.67 h / 0 °C / Inert atmosphere; Reflux

5: trifluoroacetic acid / 2.5 h / 20 °C / Inert atmosphere

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; iron; potassium carbonate; ammonium chloride; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; isopropyl alcohol; 3: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2012.08.029