methyl 2-(2-methoxyphenyl)-3-methyl-1-phenylcycloprop-2-ene-1-carboxylate

Base Information

• Chemical Name: methyl 2-(2-methoxyphenyl)-3-methyl-1-phenylcycloprop-2-ene-1-carboxylate
• CAS No.: 1400576-24-0
• Molecular Formula: C₁₉H₁₈O₃
• Molecular Weight: 294.35
• Mol file: 1400576-24-0.mol

Synonyms:methyl 2-(2-methoxyphenyl)-3-methyl-1-phenylcycloprop-2-ene-1-carboxylate

Chemical Property of methyl 2-(2-methoxyphenyl)-3-methyl-1-phenylcycloprop-2-ene-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of methyl 2-(2-methoxyphenyl)-3-methyl-1-phenylcycloprop-2-ene-1-carboxylate

There total 3 articles about methyl 2-(2-methoxyphenyl)-3-methyl-1-phenylcycloprop-2-ene-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

Methyl phenyldiazoacetate (22979-35-7) + (o-methoxyphenyl)-1-propyne (66021-98-5) → methyl 2-(2-methoxyphenyl)-3-methyl-1-phenylcycloprop-2-ene-1-carboxylate (1400576-24-0)

Guidance literature:

With copper(l) iodide; In neat (no solvent); at 110 ℃; for 16h; stereoselective reaction; Inert atmosphere;

DOI:10.1039/c2ob26295a

Reference yield:

benzeneacetic acid methyl ester (101-41-7) → methyl 2-(2-methoxyphenyl)-3-methyl-1-phenylcycloprop-2-ene-1-carboxylate (1400576-24-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 20 °C

2: copper(l) iodide / neat (no solvent) / 16 h / 110 °C / Inert atmosphere

With copper(l) iodide; 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile;

DOI:10.1039/c2ob26295a

Reference yield:

2-ethylanisole (14804-32-1) → methyl 2-(2-methoxyphenyl)-3-methyl-1-phenylcycloprop-2-ene-1-carboxylate (1400576-24-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C

1.2: 1 h / -78 °C

2.1: copper(l) iodide / neat (no solvent) / 16 h / 110 °C / Inert atmosphere

With copper(l) iodide; n-butyllithium; In tetrahydrofuran;

DOI:10.1039/c2ob26295a

upstream raw materials:

benzeneacetic acid methyl ester

Methyl phenyldiazoacetate

(o-methoxyphenyl)-1-propyne

2-ethylanisole