acetic acid 2-(6-chloro-pyridin-3-ylmethyl)-1-(1-nitro-propyl)-cyclohexyl ester

Base Information

Chemical Name:acetic acid 2-(6-chloro-pyridin-3-ylmethyl)-1-(1-nitro-propyl)-cyclohexyl ester
CAS No.:218619-22-8
Molecular Formula:C₁₇H₂₃ClN₂O₄
Molecular Weight:354.834
Hs Code.:

Synonyms:acetic acid 2-(6-chloro-pyridin-3-ylmethyl)-1-(1-nitro-propyl)-cyclohexyl ester

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Chemical Property of acetic acid 2-(6-chloro-pyridin-3-ylmethyl)-1-(1-nitro-propyl)-cyclohexyl ester

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Technology Process of acetic acid 2-(6-chloro-pyridin-3-ylmethyl)-1-(1-nitro-propyl)-cyclohexyl ester

There total 5 articles about acetic acid 2-(6-chloro-pyridin-3-ylmethyl)-1-(1-nitro-propyl)-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 108-24-7
acetic anhydride

: 218619-16-0
2-(6-chloro-pyridin-3-ylmethyl)-1-(1-nitro-propyl)-cyclohexanol

: 218619-22-8
acetic acid 2-(6-chloro-pyridin-3-ylmethyl)-1-(1-nitro-propyl)-cyclohexyl ester

Guidance literature:: sulfuric acid; In trifluoroacetic acid; at 60 ℃;
DOI:10.1002/(SICI)1096-9063(1998110)54:3<304::AID-PS832>3.0.CO;2-Z

Reference yield:

: 70258-18-3
2-chloro-5-(chloromethyl)pyridine

: 218619-22-8
acetic acid 2-(6-chloro-pyridin-3-ylmethyl)-1-(1-nitro-propyl)-cyclohexyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / NaH / tetrahydrofuran / 24 h / Heating

2: 94 percent / HCl / H₂O

3: 85 percent / Butyllithium / tetrahydrofuran; hexamethylphosphoric acid triamide / 3 h / -70 °C

4: 59 percent / H₂SO₄ / trifluoroacetic acid / 60 °C

With hydrogenchloride; n-butyllithium; sodium hydride; sulfuric acid; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; water; trifluoroacetic acid; 1: Alkylation / 2: Hydrolysis / 3: Condensation / 4: Acetylation;
DOI:10.1002/(SICI)1096-9063(1998110)54:3<304::AID-PS832>3.0.CO;2-Z

Reference yield:

: 1655-07-8
ethyl 2-oxocyclohexane carboxylate

: 218619-22-8
acetic acid 2-(6-chloro-pyridin-3-ylmethyl)-1-(1-nitro-propyl)-cyclohexyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / NaH / tetrahydrofuran / 24 h / Heating

2: 94 percent / HCl / H₂O

3: 85 percent / Butyllithium / tetrahydrofuran; hexamethylphosphoric acid triamide / 3 h / -70 °C

4: 59 percent / H₂SO₄ / trifluoroacetic acid / 60 °C

With hydrogenchloride; n-butyllithium; sodium hydride; sulfuric acid; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; water; trifluoroacetic acid; 1: Alkylation / 2: Hydrolysis / 3: Condensation / 4: Acetylation;
DOI:10.1002/(SICI)1096-9063(1998110)54:3<304::AID-PS832>3.0.CO;2-Z