N,N-dibenzyl-N-(2-adamant-1-yl-7,8-dibenzyloxy-2H-chromen-4-ylmethyl)amine

Base Information

Chemical Name:N,N-dibenzyl-N-(2-adamant-1-yl-7,8-dibenzyloxy-2H-chromen-4-ylmethyl)amine
CAS No.:1313175-21-1
Molecular Formula:C₄₈H₄₉NO₃
Molecular Weight:687.922
Hs Code.:

Synonyms:N,N-dibenzyl-N-(2-adamant-1-yl-7,8-dibenzyloxy-2H-chromen-4-ylmethyl)amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N,N-dibenzyl-N-(2-adamant-1-yl-7,8-dibenzyloxy-2H-chromen-4-ylmethyl)amine

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Technology Process of N,N-dibenzyl-N-(2-adamant-1-yl-7,8-dibenzyloxy-2H-chromen-4-ylmethyl)amine

There total 8 articles about N,N-dibenzyl-N-(2-adamant-1-yl-7,8-dibenzyloxy-2H-chromen-4-ylmethyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: C₄₈H₅₁NO₄

: 1313175-21-1
N,N-dibenzyl-N-(2-adamant-1-yl-7,8-dibenzyloxy-2H-chromen-4-ylmethyl)amine

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 20 ℃; for 1h; Inert atmosphere;
DOI:10.1002/cmdc.201100010

Reference yield:

: 1313007-75-8
7,8-dibenzyloxy-2-oxo-2H-chromene-4-carboxaldehyde

: 1313175-21-1
N,N-dibenzyl-N-(2-adamant-1-yl-7,8-dibenzyloxy-2H-chromen-4-ylmethyl)amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / chloroform / 14 h / 20 °C / Inert atmosphere

1.2: 2.5 h / 20 °C / Inert atmosphere; Cooling with ice

2.1: potassium carbonate / N,N-dimethyl-formamide / 110 °C / Inert atmosphere

3.1: diisobutylaluminium hydride / hexane; dichloromethane / 2.17 h / -78 °C / Inert atmosphere

4.1: methylmagnesium bromide; iodine; magnesium / diethyl ether / 0.5 h / 20 °C / Inert atmosphere; Reflux

4.2: 1 h / 20 °C / Inert atmosphere; Cooling

5.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

With methylmagnesium bromide; iodine; diisobutylaluminium hydride; sodium carbonate; potassium carbonate; magnesium; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; chloroform; N,N-dimethyl-formamide; 5.1: Mitsunobu reaction;
DOI:10.1002/cmdc.201100010

Reference yield:

: 1313007-78-1
7,8-dibenzyloxy-4-N,N-dibenzylaminomethylchromen-2-ol

: 1313175-21-1
N,N-dibenzyl-N-(2-adamant-1-yl-7,8-dibenzyloxy-2H-chromen-4-ylmethyl)amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: methylmagnesium bromide; iodine; magnesium / diethyl ether / 0.5 h / 20 °C / Inert atmosphere; Reflux

1.2: 1 h / 20 °C / Inert atmosphere; Cooling

2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

With methylmagnesium bromide; iodine; magnesium; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; 2.1: Mitsunobu reaction;
DOI:10.1002/cmdc.201100010