methyl 3-(1-((6-((cis-4-isopropylcyclohexyl)oxy)quinolin-2-yl)methyl)azetidin-3-yl)cyclohexanecarboxylate

Base Information

Chemical Name:methyl 3-(1-((6-((cis-4-isopropylcyclohexyl)oxy)quinolin-2-yl)methyl)azetidin-3-yl)cyclohexanecarboxylate
CAS No.:1544662-39-6
Molecular Formula:C₃₀H₄₂N₂O₃
Molecular Weight:478.675
Hs Code.:

Synonyms:methyl 3-(1-((6-((cis-4-isopropylcyclohexyl)oxy)quinolin-2-yl)methyl)azetidin-3-yl)cyclohexanecarboxylate

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Chemical Property of methyl 3-(1-((6-((cis-4-isopropylcyclohexyl)oxy)quinolin-2-yl)methyl)azetidin-3-yl)cyclohexanecarboxylate

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Technology Process of methyl 3-(1-((6-((cis-4-isopropylcyclohexyl)oxy)quinolin-2-yl)methyl)azetidin-3-yl)cyclohexanecarboxylate

There total 4 articles about methyl 3-(1-((6-((cis-4-isopropylcyclohexyl)oxy)quinolin-2-yl)methyl)azetidin-3-yl)cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 1544662-17-0
6-((cis-4-isopropylcyclohexyl)oxy)quinoline-2-carbaldehyde

: 1203796-67-1
methyl 3-(azetidin-3-yl)cyclohexanecarboxylate

: 1544662-39-6
methyl 3-(1-((6-((cis-4-isopropylcyclohexyl)oxy)quinolin-2-yl)methyl)azetidin-3-yl)cyclohexanecarboxylate

Guidance literature:: With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 1544662-13-6
6-((cis-4-isopropylcyclohexyl)oxy)-2-methylquinoline

: 1544662-39-6
methyl 3-(1-((6-((cis-4-isopropylcyclohexyl)oxy)quinolin-2-yl)methyl)azetidin-3-yl)cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: selenium(IV) oxide / toluene / 6 h / Reflux

2: sodium tris(acetoxy)borohydride / dichloromethane / 4 h / 20 °C

With selenium(IV) oxide; sodium tris(acetoxy)borohydride; In dichloromethane; toluene;

Reference yield:

: 1078-28-0
6-methoxyquinaldine

: 1544662-39-6
methyl 3-(1-((6-((cis-4-isopropylcyclohexyl)oxy)quinolin-2-yl)methyl)azetidin-3-yl)cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: boron tribromide / dichloromethane / 16 h / -78 - 20 °C

2: di-isopropyl azodicarboxylate; triphenylphosphine / toluene / 24 h / 0 - 20 °C / Inert atmosphere

3: selenium(IV) oxide / toluene / 6 h / Reflux

4: sodium tris(acetoxy)borohydride / dichloromethane / 4 h / 20 °C

With selenium(IV) oxide; di-isopropyl azodicarboxylate; boron tribromide; sodium tris(acetoxy)borohydride; triphenylphosphine; In dichloromethane; toluene;