C₄₈H₈₂INO₁₀Si₂

Base Information

Chemical Name:C₄₈H₈₂INO₁₀Si₂
CAS No.:1414941-25-5
Molecular Formula:C₄₈H₈₂INO₁₀Si₂
Molecular Weight:1016.26
Hs Code.:

C<sub>48</sub>H<sub>82</sub>INO<sub>10</sub>Si<sub>2</sub>

Synonyms:C₄₈H₈₂INO₁₀Si₂

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Chemical Property of C₄₈H₈₂INO₁₀Si₂

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Technology Process of C₄₈H₈₂INO₁₀Si₂

There total 37 articles about C₄₈H₈₂INO₁₀Si₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1392284-78-4
(3S,5R,E)-3-((tert-butyldimethylsilyl)oxy)-7-iodo-5-methoxyhept-6-enoic acid

: 1392284-89-7
(2S,4S,6S,7S)-2-[(tert-butyldimethylsilyl)oxy]-6-methoxy-8-[(4-methoxybenzyl)oxy]-1-{4-[(S)-1-methoxybut-3-en-1-yl]oxazol-2-yl}-3,3,7-trimethyloctan-4-ol

: 1414941-25-5
C₄₈H₈₂INO₁₀Si₂

Guidance literature:: (3S,5R,E)-3-((tert-butyldimethylsilyl)oxy)-7-iodo-5-methoxyhept-6-enoic acid; (2S,4S,6S,7S)-2-[(tert-butyldimethylsilyl)oxy]-6-methoxy-8-[(4-methoxybenzyl)oxy]-1-{4-[(S)-1-methoxybut-3-en-1-yl]oxazol-2-yl}-3,3,7-trimethyloctan-4-ol; With 2,4,6-trichlorobenzoyl chloride; triethylamine; In toluene; at 0 - 20 ℃; for 3h;

With dmap; In toluene; for 1.5h;
DOI:10.1002/chem.201302197

Reference yield:

: 171822-71-2
(1R,2S)-N-tert-butoxycarbonyl-[1-(tert-butyldimethylsilyloxymethyl)-2-hydroxypent-4-enyl]amine

: 1414941-25-5
C₄₈H₈₂INO₁₀Si₂

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

2.1: trifluoroacetic acid / water; dichloromethane / 4 h / 20 °C

3.1: triethylamine / tetrahydrofuran / 20 °C

4.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dichloromethane; dimethyl sulfoxide / 4.5 h / 20 °C

5.1: 2,6-di-tert-butyl-4-methylpyridine; triphenylphosphine / dichloromethane / 0.33 h / 20 °C / Inert atmosphere

5.2: 15 h / 0 °C

5.3: 5 h / 0 °C

6.1: C₄H₁₀O*H₂Mg*2Br^(1-); dimethylsulfide / dichloromethane / 18 h / 20 °C / Sealed tube

7.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 2 h / 20 °C

8.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 - -40 °C

8.2: 0.58 h / -40 °C

9.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 °C

9.2: 1.08 h / 10 °C

10.1: triethylamine; 2,4,6-trichlorobenzoyl chloride / toluene / 3 h / 0 - 20 °C

10.2: 1.5 h

With 2,6-di-tert-butyl-4-methylpyridine; dimethylsulfide; 2,4,6-trichlorobenzoyl chloride; C₄H₁₀O*H₂Mg*2Br^(1-); sodium hydride; triethylamine; triphenylphosphine; trifluoroacetic acid; lithium hexamethyldisilazane; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1002/chem.201302197

Reference yield:

: (4R,5S)-5-allyl-4-(tert-butyl-dimethyl-silanyloxymethyl)-oxazolidin-2-one

: 1414941-25-5
C₄₈H₈₂INO₁₀Si₂

Guidance literature:: Multi-step reaction with 12 steps

1.1: trifluoroacetic acid / water; dichloromethane / 4 h / 20 °C

2.1: triethylamine / tetrahydrofuran / 20 °C

3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dichloromethane; dimethyl sulfoxide / 4.5 h / 20 °C

4.1: 2,6-di-tert-butyl-4-methylpyridine; triphenylphosphine / dichloromethane / 0.33 h / 20 °C / Inert atmosphere

4.2: 15 h / 0 °C

4.3: 5 h / 0 °C

5.1: C₄H₁₀O*H₂Mg*2Br^(1-); dimethylsulfide / dichloromethane / 18 h / 20 °C / Sealed tube

6.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 2 h / 20 °C

7.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 - -40 °C

7.2: 0.58 h / -40 °C

8.1: triethylamine; dicyclohexylboron chloride / tetrahydrofuran; diethyl ether / 1.5 h / -30 °C

8.2: 1.5 h / -78 °C

9.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 °C

9.2: 0.67 h / 0 °C

10.1: pyridinium chlorochromate / dichloromethane / 1.5 h / 20 °C / Reflux

11.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.75 h / -90 °C / Inert atmosphere

11.2: 20 °C / Inert atmosphere

12.1: triethylamine; 2,4,6-trichlorobenzoyl chloride / toluene / 3 h / 0 - 20 °C

12.2: 1.5 h

With lithium aluminium tetrahydride; 2,6-di-tert-butyl-4-methylpyridine; dimethylsulfide; 2,4,6-trichlorobenzoyl chloride; C₄H₁₀O*H₂Mg*2Br^(1-); dicyclohexylboron chloride; sodium hydride; triethylamine; triphenylphosphine; pyridinium chlorochromate; trifluoroacetic acid; lithium hexamethyldisilazane; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; diethyl ether; dichloromethane; water; dimethyl sulfoxide; toluene; mineral oil;
DOI:10.1002/chem.201302197