6-ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

Base Information

Chemical Name:6-ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide
CAS No.:1268476-92-1
Molecular Formula:C₂₆H₃₀N₄O₅
Molecular Weight:478.548
Hs Code.:

Synonyms:6-ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

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Chemical Property of 6-ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

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Technology Process of 6-ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

There total 9 articles about 6-ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 2-(4-aminopiperidin-1-yl)-2-oxoethanol hydrochloride

: 1268476-91-0
6-ethyl-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid

: 1268476-92-1
6-ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 10 - 35 ℃; for 72h;

Reference yield:

: 30414-53-0
methyl propanoyl acetate

: 1268476-92-1
6-ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1: ammonium acetate / methanol / 72 h / 10 - 35 °C

2: sodium ethanolate / ethanol / 15 h / 150 °C

3: trichlorophosphate / 0.5 h / 80 °C

4: potassium carbonate / N,N-dimethyl-formamide / 15 h / 10 - 35 °C

5: triethylamine / ethanol / 25 h / 80 - 100 °C

6: pyridine / 3 h / 60 °C / Inert atmosphere

7: triethylamine; formic acid; tributylphosphine / palladium diacetate / N,N-dimethyl-formamide / 8 h / Reflux; Inert atmosphere

8: sodium hydroxide; water / ethanol; tetrahydrofuran / 1.5 h / 60 °C

9: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 72 h / 10 - 35 °C

With pyridine; formic acid; tributylphosphine; ammonium acetate; water; sodium ethanolate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; trichlorophosphate; palladium diacetate; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 883528-73-2
3-amino-4-methyl crotonic acid methylester

: 1268476-92-1
6-ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1: sodium ethanolate / ethanol / 15 h / 150 °C

2: trichlorophosphate / 0.5 h / 80 °C

3: potassium carbonate / N,N-dimethyl-formamide / 15 h / 10 - 35 °C

4: triethylamine / ethanol / 25 h / 80 - 100 °C

5: pyridine / 3 h / 60 °C / Inert atmosphere

6: triethylamine; formic acid; tributylphosphine / palladium diacetate / N,N-dimethyl-formamide / 8 h / Reflux; Inert atmosphere

7: sodium hydroxide; water / ethanol; tetrahydrofuran / 1.5 h / 60 °C

8: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 72 h / 10 - 35 °C

With pyridine; formic acid; tributylphosphine; water; sodium ethanolate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; trichlorophosphate; palladium diacetate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;