N-[8-chloro-2,3,4,5-tetrahydro-3-methyl-6-nitro-5(R)-phenyl-1H-3-benzazepin-7-yl]-2-hydroxyacetamide

Base Information

Chemical Name:N-[8-chloro-2,3,4,5-tetrahydro-3-methyl-6-nitro-5(R)-phenyl-1H-3-benzazepin-7-yl]-2-hydroxyacetamide
CAS No.:668476-51-5
Molecular Formula:C₁₉H₂₀ClN₃O₄
Molecular Weight:389.838
Hs Code.:

Synonyms:N-[8-chloro-2,3,4,5-tetrahydro-3-methyl-6-nitro-5(R)-phenyl-1H-3-benzazepin-7-yl]-2-hydroxyacetamide

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Chemical Property of N-[8-chloro-2,3,4,5-tetrahydro-3-methyl-6-nitro-5(R)-phenyl-1H-3-benzazepin-7-yl]-2-hydroxyacetamide

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Technology Process of N-[8-chloro-2,3,4,5-tetrahydro-3-methyl-6-nitro-5(R)-phenyl-1H-3-benzazepin-7-yl]-2-hydroxyacetamide

There total 4 articles about N-[8-chloro-2,3,4,5-tetrahydro-3-methyl-6-nitro-5(R)-phenyl-1H-3-benzazepin-7-yl]-2-hydroxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 668476-50-4
2-[[8-chloro-2,3,4,5-tetrahydro-3-methyl-6-nitro-5(R)-phenyl-1H-3-benzazepin-7-yl]oxy]acetamide

: 668476-51-5
N-[8-chloro-2,3,4,5-tetrahydro-3-methyl-6-nitro-5(R)-phenyl-1H-3-benzazepin-7-yl]-2-hydroxyacetamide

Guidance literature:: With sodium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1021/jm030614p

Reference yield:

: 73445-63-3,84384-04-3,87075-17-0,95191-55-2
SCH 23390

: 668476-51-5
N-[8-chloro-2,3,4,5-tetrahydro-3-methyl-6-nitro-5(R)-phenyl-1H-3-benzazepin-7-yl]-2-hydroxyacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / HNO₃; HCOOH / 20 °C

2: 3.89 g / K₂CO₃ / acetone / 70 h / Heating

3: 1.7 g / NaOH / dimethylformamide / 2 h / 20 °C

With sodium hydroxide; formic acid; nitric acid; potassium carbonate; In N,N-dimethyl-formamide; acetone; 3: Smiles rearrangement;
DOI:10.1021/jm030614p

Reference yield:

: 668476-49-1
8-chloro-2,3,4,5-tetrahydro-3-methyl-6-nitro-5(R)-phenyl-1H-3-benzazepin-7-ol

: 668476-51-5
N-[8-chloro-2,3,4,5-tetrahydro-3-methyl-6-nitro-5(R)-phenyl-1H-3-benzazepin-7-yl]-2-hydroxyacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 3.89 g / K₂CO₃ / acetone / 70 h / Heating

2: 1.7 g / NaOH / dimethylformamide / 2 h / 20 °C

With sodium hydroxide; potassium carbonate; In N,N-dimethyl-formamide; acetone; 2: Smiles rearrangement;
DOI:10.1021/jm030614p