3-(4-chlorophenyl)-5,6,7,8-tetrahydro-10,11-dimethoxy-6-methyl-4H-isoxazolo<4,5-g><3>benzazonine

Base Information

• Chemical Name: 3-(4-chlorophenyl)-5,6,7,8-tetrahydro-10,11-dimethoxy-6-methyl-4H-isoxazolo<4,5-g><3>benzazonine
• CAS No.: 123420-57-5
• Molecular Formula: C₂₂H₂₃ClN₂O₃
• Molecular Weight: 398.889
• Mol file: 123420-57-5.mol

Synonyms:3-(4-chlorophenyl)-5,6,7,8-tetrahydro-10,11-dimethoxy-6-methyl-4H-isoxazolo<4,5-g><3>benzazonine

Chemical Property of 3-(4-chlorophenyl)-5,6,7,8-tetrahydro-10,11-dimethoxy-6-methyl-4H-isoxazolo<4,5-g><3>benzazonine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-chlorophenyl)-5,6,7,8-tetrahydro-10,11-dimethoxy-6-methyl-4H-isoxazolo<4,5-g><3>benzazonine

There total 4 articles about 3-(4-chlorophenyl)-5,6,7,8-tetrahydro-10,11-dimethoxy-6-methyl-4H-isoxazolo<4,5-g><3>benzazonine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(3RS,9bRS,12aRS)-12-(4-chlorophenyl)-1,4,5,12a-tetrahydro-7,8-dimethoxy-3-methyl-2H-isoxazolo<5',4':2,3>pyrrolo<2,1-a>isoquinolinium iodide (133964-03-1) → 3-(4-chlorophenyl)-5,6,7,8-tetrahydro-10,11-dimethoxy-6-methyl-4H-isoxazolo<4,5-g><3>benzazonine (123420-57-5)

Guidance literature:

With sodium methylate; In methanol; Ambient temperature;

DOI:10.1016/S0040-4039(00)99495-4

Reference yield:

8,9-dimethoxy-2,3,5,6-tetrahydro-1H-pyrrolo[2,1-a]isoquinolinium; bromide (123420-50-8) → 3-(4-chlorophenyl)-5,6,7,8-tetrahydro-10,11-dimethoxy-6-methyl-4H-isoxazolo<4,5-g><3>benzazonine (123420-57-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent / Et₃N / CHCl₃ / 1) ice bath, 2) 25 deg C

2: 96 percent / Heating

3: 92 percent / NaOMe / methanol / 2 h / 25 °C

With sodium methylate; triethylamine; In methanol; chloroform;

DOI:10.1021/jo00015a025

Reference yield:

(9bRS,12aRS)-12-(4-chlorophenyl)-1,4,5,12a-tetrahydro-7,8-dimethoxy-2H-isoxazolo<5',4':2,3>pyrrolo<2,1-a>isoquinoline (133964-02-0) → 3-(4-chlorophenyl)-5,6,7,8-tetrahydro-10,11-dimethoxy-6-methyl-4H-isoxazolo<4,5-g><3>benzazonine (123420-57-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / Heating

2: 92 percent / NaOMe / methanol / 2 h / 25 °C

With sodium methylate; In methanol;

DOI:10.1021/jo00015a025

upstream raw materials:

(3RS,9bRS,12aRS)-12-(4-chlorophenyl)-1,4,5,12a-tetrahydro-7,8-dimethoxy-3-methyl-2H-isoxazolo<5',4':2,3>pyrrolo<2,1-a>isoquinolinium iodide

8,9-dimethoxy-2,3,5,6-tetrahydro-1H-pyrrolo[2,1-a]isoquinolinium; bromide

(9bRS,12aRS)-12-(4-chlorophenyl)-1,4,5,12a-tetrahydro-7,8-dimethoxy-2H-isoxazolo<5',4':2,3>pyrrolo<2,1-a>isoquinoline

4-chlorobenzohydroximoyl chloride