2-(hydroxy(1-(4-(trifluoromethyl)phenyl)cyclobutyl)methyl)cyclopentanone

Base Information

Chemical Name:2-(hydroxy(1-(4-(trifluoromethyl)phenyl)cyclobutyl)methyl)cyclopentanone
CAS No.:1432492-84-6
Molecular Formula:C₁₇H₁₉F₃O₂
Molecular Weight:312.332
Hs Code.:

Synonyms:2-(hydroxy(1-(4-(trifluoromethyl)phenyl)cyclobutyl)methyl)cyclopentanone

Suppliers and Price of 2-(hydroxy(1-(4-(trifluoromethyl)phenyl)cyclobutyl)methyl)cyclopentanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(hydroxy(1-(4-(trifluoromethyl)phenyl)cyclobutyl)methyl)cyclopentanone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(hydroxy(1-(4-(trifluoromethyl)phenyl)cyclobutyl)methyl)cyclopentanone

There total 3 articles about 2-(hydroxy(1-(4-(trifluoromethyl)phenyl)cyclobutyl)methyl)cyclopentanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1-(4-(trifluoromethyl)phenyl)cyclobutanecarbaldehyde

: 120-92-3
cyclopentanone

: 1432492-84-6
2-(hydroxy(1-(4-(trifluoromethyl)phenyl)cyclobutyl)methyl)cyclopentanone

Guidance literature:: cyclopentanone; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

1-(4-(trifluoromethyl)phenyl)cyclobutanecarbaldehyde; In tetrahydrofuran; at -78 - 20 ℃;

Reference yield:

: 2338-75-2
4-(Trifluoromethyl)phenylacetonitrile

: 1432492-84-6
2-(hydroxy(1-(4-(trifluoromethyl)phenyl)cyclobutyl)methyl)cyclopentanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / dimethyl sulfoxide; diethyl ether / 4 h / 0 - 20 °C

2.1: diisobutylaluminium hydride / dichloromethane / 2.5 h / -78 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

3.2: -78 - 20 °C

With sodium hydride; diisobutylaluminium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 29786-44-5
1-(4-(trifluoromethyl)phenyl)cyclobutane-1-carbonitrile

: 1432492-84-6
2-(hydroxy(1-(4-(trifluoromethyl)phenyl)cyclobutyl)methyl)cyclopentanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisobutylaluminium hydride / dichloromethane / 2.5 h / -78 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

2.2: -78 - 20 °C

With diisobutylaluminium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;