2-MALEIMIDOETHYLAMINE HCL

Base Information

• Chemical Name: 2-MALEIMIDOETHYLAMINE HCL
• CAS No.: 134272-64-3
• Molecular Formula: C6H8 N2 O2 . Cl H
• Molecular Weight: 176.603
• Hs Code.: 2925190090
• Mol file: 134272-64-3.mol

Synonyms:1H-Pyrrole-2,5-dione,1-(2-aminoethyl)-, monohydrochloride (9CI)

Chemical Property of 2-MALEIMIDOETHYLAMINE HCL

Chemical Property:

• Vapor Pressure: 0.000513mmHg at 25°C
• Melting Point: 163 °C(dec.)
• Boiling Point: 308.2°Cat760mmHg
• Flash Point: 140.2°C
• PSA: 63.40000
• Density: g/cm³
• LogP: 0.31030
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: soluble in Methanol

Purity/Quality:

97% ^*data from raw suppliers

2-MaleimidoethylamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Maleimidoethylamine Hydrochloride is used in preparation of Maytansinoid-peptide conjugates as therapeutics.

Technology Process of 2-MALEIMIDOETHYLAMINE HCL

There total 1 articles about 2-MALEIMIDOETHYLAMINE HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.2%

N-[2-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-ethyl]-carbamic acid tert-butyl ester (134272-63-2) → 2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethanaminium chloride (134272-64-3)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 8h;

Reference yield: 82.0%

2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethanaminium chloride (134272-64-3) + (E)-perfluorophenyl 4-(phenyldiazenyl)benzoate → (E)-N-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)-4-(phenyldiazenyl)benzamide

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1016/j.bioorg.2014.10.004

Reference yield: 80.0%

4-cyclooct-2-ynylmethylbenzoic acid (886209-53-6) + 2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethanaminium chloride (134272-64-3) → C22H24N2O3 (1133357-81-9)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In acetonitrile; at 20 ℃; for 2h;

DOI:10.1002/anie.200804514

upstream raw materials:

N-[2-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-ethyl]-carbamic acid tert-butyl ester

Downstream raw materials:

C₂₂H₂₄N₂O₃

C₁₃H₁₁N₅O₄

trifluoroacetic acid

5-(dimethylamino)-N-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)naphthalene-1-sulfonamide

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