(2R,5R)-2-(tert-butyl)-3-(3,5-dichlorophenyl)-5-[⁽²⁾H₃]methyl-1-(2,2,2-trifluoroacetyl)-5-[[4-(trifluoromethoxy)phenyl]methyl]imidazolidin-4-one

Base Information

• Chemical Name: (2R,5R)-2-(tert-butyl)-3-(3,5-dichlorophenyl)-5-[⁽²⁾H₃]methyl-1-(2,2,2-trifluoroacetyl)-5-[[4-(trifluoromethoxy)phenyl]methyl]imidazolidin-4-one
• CAS No.: 1356584-75-2
• Molecular Formula: C₂₄H₂₂Cl₂F₆N₂O₃
• Molecular Weight: 574.323

Synonyms:(2R,5R)-2-(tert-butyl)-3-(3,5-dichlorophenyl)-5-[⁽²⁾H₃]methyl-1-(2,2,2-trifluoroacetyl)-5-[[4-(trifluoromethoxy)phenyl]methyl]imidazolidin-4-one

Chemical Property of (2R,5R)-2-(tert-butyl)-3-(3,5-dichlorophenyl)-5-[⁽²⁾H₃]methyl-1-(2,2,2-trifluoroacetyl)-5-[[4-(trifluoromethoxy)phenyl]methyl]imidazolidin-4-one

Chemical Property:

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Safty Information:

• Pictogram(s):  
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Technology Process of (2R,5R)-2-(tert-butyl)-3-(3,5-dichlorophenyl)-5-[⁽²⁾H₃]methyl-1-(2,2,2-trifluoroacetyl)-5-[[4-(trifluoromethoxy)phenyl]methyl]imidazolidin-4-one

There total 5 articles about (2R,5R)-2-(tert-butyl)-3-(3,5-dichlorophenyl)-5-[⁽²⁾H₃]methyl-1-(2,2,2-trifluoroacetyl)-5-[[4-(trifluoromethoxy)phenyl]methyl]imidazolidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

(2S,5R)-2-(tert-butyl)-3-(3,5-dichlorophenyl)-5-[(2)H3]methyl-1-(2,2,2-trifluoroacetyl)imidazolidin-4-one (1356584-73-0) + 4-trifluoromethoxybenzyl bromide (50824-05-0) → (2R,5R)-2-(tert-butyl)-3-(3,5-dichlorophenyl)-5-[(2)H3]methyl-1-(2,2,2-trifluoroacetyl)-5-[[4-(trifluoromethoxy)phenyl]methyl]imidazolidin-4-one (1356584-75-2)

Guidance literature:

(2S,5R)-2-(tert-butyl)-3-(3,5-dichlorophenyl)-5-[⁽²⁾H₃]methyl-1-(2,2,2-trifluoroacetyl)imidazolidin-4-one; With lithium hexamethyldisilazane; In tetrahydrofuran; at -20 - -15 ℃; for 2h; Inert atmosphere;

4-trifluoromethoxybenzyl bromide; In tetrahydrofuran; at -15 - 20 ℃;

DOI:10.1002/jlcr.1934

Reference yield:

[(R)-1-(3,5-dichlorophenylcarbamoyl)[2,2,2-(2)H3]ethyl]carbamic acid tert-butyl ester (1356584-67-2) → (2R,5R)-2-(tert-butyl)-3-(3,5-dichlorophenyl)-5-[(2)H3]methyl-1-(2,2,2-trifluoroacetyl)-5-[[4-(trifluoromethoxy)phenyl]methyl]imidazolidin-4-one (1356584-75-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrogenchloride; water / methanol / 0 - 20 °C

1.2: Cooling with ice

2.1: toluene / 55 °C

3.1: triethylamine / dichloromethane / 0.17 h / -5 °C

3.2: -5 - 20 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -20 - -15 °C / Inert atmosphere

4.2: -15 - 20 °C

With hydrogenchloride; water; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; toluene;

DOI:10.1002/jlcr.1934

Reference yield:

(R)-2-amino-N-(3,5-dichlorophenyl)[3,3,3-(2)H]propionamide (1356584-69-4) → (2R,5R)-2-(tert-butyl)-3-(3,5-dichlorophenyl)-5-[(2)H3]methyl-1-(2,2,2-trifluoroacetyl)-5-[[4-(trifluoromethoxy)phenyl]methyl]imidazolidin-4-one (1356584-75-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: toluene / 55 °C

2.1: triethylamine / dichloromethane / 0.17 h / -5 °C

2.2: -5 - 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -20 - -15 °C / Inert atmosphere

3.2: -15 - 20 °C

With triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1002/jlcr.1934

upstream raw materials:

[(R)-1-(3,5-dichlorophenylcarbamoyl)[2,2,2-⁽²⁾H₃]ethyl]carbamic acid tert-butyl ester

(R)-2-amino-N-(3,5-dichlorophenyl)[3,3,3-⁽²⁾H]propionamide

(2S,5R)-2-(tert-butyl)-3-(3,5-dichlorophenyl)-5-([⁽²⁾H₃]methyl)imidazolidin-4-one

(2S,5R)-2-(tert-butyl)-3-(3,5-dichlorophenyl)-5-[⁽²⁾H₃]methyl-1-(2,2,2-trifluoroacetyl)imidazolidin-4-one

Downstream raw materials:

tert-butyl N-[2-[[(1R)-2-(3,5-dichloroanilino)-1-[⁽²⁾H₃]methyl-2-oxo-1-[[4-(trifluoromethoxy)phenyl]methyl]ethyl]amino]-2-oxo[⁽¹³⁾C₂]ethyl]carbamate

(2R)-2-amino-N-(3,5-dichlorophenyl)-2-[⁽²⁾H₃]methyl-3-[4-(trifluoromethoxy)phenyl]propanamide

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