7-(4-iodo-phenyl)-9-(4-methoxy-phenyl)-7H-pyrrolo[3,2-e]tetrazolo[1,5-c]pyrimidine

Base Information

• Chemical Name: 7-(4-iodo-phenyl)-9-(4-methoxy-phenyl)-7H-pyrrolo[3,2-e]tetrazolo[1,5-c]pyrimidine
• CAS No.: 220835-54-1
• Molecular Formula: C₁₉H₁₃IN₆O
• Molecular Weight: 468.256

Synonyms:7-(4-iodo-phenyl)-9-(4-methoxy-phenyl)-7H-pyrrolo[3,2-e]tetrazolo[1,5-c]pyrimidine

Chemical Property of 7-(4-iodo-phenyl)-9-(4-methoxy-phenyl)-7H-pyrrolo[3,2-e]tetrazolo[1,5-c]pyrimidine

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Technology Process of 7-(4-iodo-phenyl)-9-(4-methoxy-phenyl)-7H-pyrrolo[3,2-e]tetrazolo[1,5-c]pyrimidine

There total 3 articles about 7-(4-iodo-phenyl)-9-(4-methoxy-phenyl)-7H-pyrrolo[3,2-e]tetrazolo[1,5-c]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

[7-(4-iodo-phenyl)-5-(4-methoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-hydrazine (220835-44-9) → 7-(4-iodo-phenyl)-9-(4-methoxy-phenyl)-7H-pyrrolo[3,2-e]tetrazolo[1,5-c]pyrimidine (220835-54-1)

Guidance literature:

With acetic acid; sodium nitrite; at 0 - 5 ℃; for 2h;

DOI:10.1002/jhet.5570350609

Reference yield: 58.0%

4-chloro-7-(4-iodo-phenyl)-5-(4-methoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidine (220835-32-5) → 7-(4-iodo-phenyl)-9-(4-methoxy-phenyl)-7H-pyrrolo[3,2-e]tetrazolo[1,5-c]pyrimidine (220835-54-1)

Guidance literature:

With sodium azide; ammonium chloride; In dimethyl sulfoxide; at 90 ℃; for 2h;

DOI:10.1002/jhet.5570350609

Reference yield:

2-Amino-1-(4-iodo-phenyl)-4-(4-methoxy-phenyl)-1H-pyrrole-3-carbonitrile (115998-19-1) → 7-(4-iodo-phenyl)-9-(4-methoxy-phenyl)-7H-pyrrolo[3,2-e]tetrazolo[1,5-c]pyrimidine (220835-54-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 76 percent / 10 h / Heating

2: 56 percent / POCl₃ / 19 h / Heating

3: 61 percent / hydrazine hydrate / ethanol / 4 h / Heating

4: 59 percent / aq. NaNO₂, AcOH / 2 h / 0 - 5 °C

With hydrazine hydrate; acetic acid; sodium nitrite; trichlorophosphate; In ethanol;

DOI:10.1002/jhet.5570350609

upstream raw materials:

4-chloro-7-(4-iodo-phenyl)-5-(4-methoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidine

[7-(4-iodo-phenyl)-5-(4-methoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-hydrazine

2-Amino-1-(4-iodo-phenyl)-4-(4-methoxy-phenyl)-1H-pyrrole-3-carbonitrile

Downstream raw materials:

7-(4-Iodo-phenyl)-5-(4-methoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine

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