{2-[({[(2S,5R)-7-oxo-6-sulphooxy-1,6-diazabicyclo[3.2.1]oct-2-yl]carbonyl}amino)oxy]ethyl}carbamic acid tert-butyl ester tetrabutylammonium

Base Information

• Chemical Name: {2-[({[(2S,5R)-7-oxo-6-sulphooxy-1,6-diazabicyclo[3.2.1]oct-2-yl]carbonyl}amino)oxy]ethyl}carbamic acid tert-butyl ester tetrabutylammonium
• CAS No.: 1501977-14-5
• Molecular Formula: C₁₄H₂₃N₄O₉S*C₁₆H₃₆N
• Molecular Weight: 665.893
• Mol file: 1501977-14-5.mol

Synonyms:{2-[({[(2S,5R)-7-oxo-6-sulphooxy-1,6-diazabicyclo[3.2.1]oct-2-yl]carbonyl}amino)oxy]ethyl}carbamic acid tert-butyl ester tetrabutylammonium

Chemical Property of {2-[({[(2S,5R)-7-oxo-6-sulphooxy-1,6-diazabicyclo[3.2.1]oct-2-yl]carbonyl}amino)oxy]ethyl}carbamic acid tert-butyl ester tetrabutylammonium

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {2-[({[(2S,5R)-7-oxo-6-sulphooxy-1,6-diazabicyclo[3.2.1]oct-2-yl]carbonyl}amino)oxy]ethyl}carbamic acid tert-butyl ester tetrabutylammonium

There total 1 articles about {2-[({[(2S,5R)-7-oxo-6-sulphooxy-1,6-diazabicyclo[3.2.1]oct-2-yl]carbonyl}amino)oxy]ethyl}carbamic acid tert-butyl ester tetrabutylammonium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S,5R)-5-hydroxypiperidine-2-carboxylic acid (63088-78-8,448964-01-0,478409-64-2) → {2-[({[(2S,5R)-7-oxo-6-sulphooxy-1,6-diazabicyclo[3.2.1]oct-2-yl]carbonyl}amino)oxy]ethyl}carbamic acid tert-butyl ester tetrabutylammonium (1501977-14-5)

Guidance literature:

Multi-step reaction with 10 steps

1.1: hydrogenchloride / 3 h / Reflux

2.1: triethylamine / tetrahydrofuran / 2.17 h / 10 - 20 °C / Cooling with ice

3.1: 2,6-dimethylpyridine; trifluoromethylsulfonic anhydride / acetonitrile / 0.67 h / -36 - -30 °C

3.2: 48 h / -32 - 4 °C

4.1: hydrogenchloride / methanol / 72 h / Reflux

5.1: potassium carbonate / ethyl acetate; water

6.1: triethylamine / acetonitrile / 0.33 h / 2 - 5 °C / Cooling with ice

6.2: 10 h / 20 °C

7.1: water; lithium hydroxide / tetrahydrofuran / 2.17 h / 2 - 4.9 °C

8.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

9.1: palladium 10% on activated carbon; hydrogen / water; methanol / 0.75 h / 20 °C

10.1: 2,6-dimethylpyridine; sulfur trioxide pyridine complex / dichloromethane / 20 °C

10.2: 0.17 h

With 2,6-dimethylpyridine; hydrogenchloride; trifluoromethylsulfonic anhydride; palladium 10% on activated carbon; water; hydrogen; sulfur trioxide pyridine complex; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; acetonitrile;

Reference yield: 99.0%

{2-[({[(2S,5R)-7-oxo-6-sulphooxy-1,6-diazabicyclo[3.2.1]oct-2-yl]carbonyl}amino)oxy]ethyl}carbamic acid tert-butyl ester tetrabutylammonium (1501977-14-5) → RG6080 (1452458-86-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at -20 - 0 ℃; for 2h; Temperature; Inert atmosphere; Large scale;

upstream raw materials:

(2S,5R)-5-hydroxypiperidine-2-carboxylic acid

Downstream raw materials:

RG₆₀₈₀