cis-2-(diphenylmethyl)-N-(2-ethylbenzoyl)-1-azabicyclo<2.2.2>octan-3-amine

Base Information

• Chemical Name: cis-2-(diphenylmethyl)-N-(2-ethylbenzoyl)-1-azabicyclo<2.2.2>octan-3-amine
• CAS No.: 141958-01-2
• Molecular Formula: C₂₉H₃₂N₂O
• Molecular Weight: 424.586
• Mol file: 141958-01-2.mol

Synonyms:cis-2-(diphenylmethyl)-N-(2-ethylbenzoyl)-1-azabicyclo<2.2.2>octan-3-amine

Chemical Property of cis-2-(diphenylmethyl)-N-(2-ethylbenzoyl)-1-azabicyclo<2.2.2>octan-3-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cis-2-(diphenylmethyl)-N-(2-ethylbenzoyl)-1-azabicyclo<2.2.2>octan-3-amine

There total 6 articles about cis-2-(diphenylmethyl)-N-(2-ethylbenzoyl)-1-azabicyclo<2.2.2>octan-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4,4'-Dibrombenzhydryl)-3-chinuclidinon (24802-70-8) → cis-2-(diphenylmethyl)-N-(2-ethylbenzoyl)-1-azabicyclo<2.2.2>octan-3-amine (141958-01-2)

Guidance literature:

Multi-step reaction with 5 steps

1: camphorsulfonic acid / toluene / 18 h / Heating

2: 9-BBN / tetrahydrofuran / 72 h / Ambient temperature

3: 48percent HBr / 2 h / 130 - 140 °C

4: 49.5 percent / 6N HCl, H₂ / 10percent Pd/C / ethanol / 7 h / 2068.6 Torr

5: tetrahydrofuran / 18 h / Heating

With hydrogenchloride; 9-borabicyclo[3.3.1]nonane dimer; camphor-10-sulfonic acid; hydrogen bromide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; toluene;

DOI:10.1021/jm00092a009

Reference yield:

cis-2--N-<3-(4-methoxyphenyl)methyl>-1-azabicyclo<2.2.2>octan-3-amine (135007-73-7) → cis-2-(diphenylmethyl)-N-(2-ethylbenzoyl)-1-azabicyclo<2.2.2>octan-3-amine (141958-01-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 48percent HBr / 2 h / 130 - 140 °C

2: 49.5 percent / 6N HCl, H₂ / 10percent Pd/C / ethanol / 7 h / 2068.6 Torr

3: tetrahydrofuran / 18 h / Heating

With hydrogenchloride; hydrogen bromide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol;

DOI:10.1021/jm00092a009

Reference yield:

[2-[Bis-(4-bromo-phenyl)-methyl]-1-aza-bicyclo[2.2.2]oct-(3E)-ylidene]-(4-methoxy-benzyl)-amine → cis-2-(diphenylmethyl)-N-(2-ethylbenzoyl)-1-azabicyclo<2.2.2>octan-3-amine (141958-01-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 9-BBN / tetrahydrofuran / 72 h / Ambient temperature

2: 48percent HBr / 2 h / 130 - 140 °C

3: 49.5 percent / 6N HCl, H₂ / 10percent Pd/C / ethanol / 7 h / 2068.6 Torr

4: tetrahydrofuran / 18 h / Heating

With hydrogenchloride; 9-borabicyclo[3.3.1]nonane dimer; hydrogen bromide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol;

DOI:10.1021/jm00092a009

upstream raw materials:

(-)-cis-2-(diphenylmethyl)-1-azabicyclo<2.2.2>octan-3-amine

2-(4,4'-Dibrombenzhydryl)-3-chinuclidinon

cis-2--N-<3-(4-methoxyphenyl)methyl>-1-azabicyclo<2.2.2>octan-3-amine

(-)-cis-2--1-azabicyclo<2.2.2>octan-3-amine

Downstream raw materials:

cis-2-(diphenylmethyl)-N-<(2-ethylphenyl)methyl>-1-azabicyclo<2.2.2>octan-3-amine